GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-methylpropene
CAS：115-11-7
Result：
| ID: | 20A2103 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
Its lower explosion limit is 1.8% (Ullmanns), which is smaller than 13%. |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Flammable gas |
| 5 | Gases under pressure | Liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Since its critical temperature is above +65degC, it was classified into a low-pressure liquefied gas. |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solid | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | It is described that in an oral gavage test (dissolved in corn oil) using rats, at a dose of 150 mg/kg, no adverse clinical effects nor mortality occurred within six hours after dosing (SIDS (accessed in August 2008)). Since this test does not provide sufficient data and due to the lack of data, the substance was classified into "Classification not possible". |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | In a 4h-inhalation test using rats, its LC50 = 270000 ppm (SIDS (accessed in August 2005)). Therefore, the substance was classified into "Not classified". |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | In a bone marrow micronucleus test by inhalation using mice (following GLP-compliant OECD TG 474) (in vivo mutagenicity test using somatic cells), the substance was negative (SIDS (accessed in August 2008)). Also, in a micronucleus test using bone marrow cells and peripheral blood cells in mice with inhalation, the substance was negative (NTP DB (accessed in August 2008)). Based on these results, the substance was classified into "Not classified". As relevant information, in all of an in vitro mutagenicity test (Ames test) (SIDS (accessed in August 2008), NTP DB (accessed in August 2008)), mouse lymphoma assay (SIDS (accessed in August 2008)), and in vitro micronucleus test using human lymphocytes (SIDS (accessed in August 2008)), the substance has been reported to be negative. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | In the NTP Two Year Carcinogenicity Study using rats and mice with inhalation, thyroid gland follicular cell carcinoma was seen only in male rats and the 8000 ppm inhalation group (5/50, male rats), but there was no concurrence with the incidence of hyperplasia or tumor of thyroid gland follicular cell. In addition, there were no increased incidences of proliferative lesions of the thyroid gland in exposed female rats compared to the chamber controls (SIDS (accessed in August 2008)). Furthermore, since tumor formation was not seen in mice, the carcinogenicity of this substance was considered to be weak (SIDS (accessed in August 2008)). Since the substance showed weak carcinogenicity in rat males but no carcinogenicity in mice, and its potency of carcinogenicity in humans could not be evaluated, the substance was classified into "Classification not possible". |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In a developmental toxicity test using rats (following GLP-compliant OECD TG 414), there was no effect of this substance on such matters as the number, growth, or survival of the fetuses in utero (SIDS (accessed in August 2008)), but the test does not provide data on fertility and sexual functions of parental animals, and therefore, the substance was classified into "Classification not possible". |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
In an inhalation exposure test, rats inhaling for 1-hour at the LC50 concentration (270000 ppm) were in a state of deep narcosis. In a similar test using mice, at concentrations 40% (400000 ppm) or higher, narcotic effects were found (SIDS (accessed in August 2008)). Therefore, the substance was classified into Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In a 13-week inhalation test using rats (6 hours/day, 5 days/week, doses of 250, 1000, and 8000 ppm), NOAEL was 8000 ppm, which is above the equivalent value of Category 2. Also, in a 14-week inhalation test using rats (6 hours/day, 5 days/week, doses of 500, 1000, 2000, 4000, and 8000 ppms), no histopathological effect was seen (SIDS (accessed in August 2008)). Furthermore, also in a 14-week inhalation test using mice, no effects other than increased kidney weight (11%: males, at 8000 ppm) (about 18%: females, at 500 ppm or more) was observed (SIDS (accessed in August 2008)). It is described that in a 28 day gavage administration test using rats, a decrease in total white blood cell count (44%: females; 11%: males) (predominantly in leucocytes and monocytes) at the dose of 150 mg/kg/day?equivalent to the guidance value of Category 2?showed statistical significance compared with those of the control group, but conclude to be within the historical data. Based on the above results, neither inhalation tests nor oral tests showed significant influences within the guidance values, and the substance should be classified into "Not classified" (inhalation, oral). However, since no information with the dermal route is available, the substance was classified into "Classification not possible". |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |