GHS Classification Result

Chemical Name：metam-sodium (ISO); sodium methyldithiocarbamate
CAS：137-42-8

Result：
ID: 20A2113
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (room temperature)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (room temperature)
5 Gases under pressure Not applicable - - - - Solid (room temperature)
6 Flammable liquids Not applicable - - - - Solid (room temperature)
7 Flammable solid Not classified - - - - Nonflammable (Merck (14th, 2006))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (room temperature)
10 Pyrophoric solids Not classified - - - - The substance is not pyrophoric (IUCLID (2000)).
11 Self-heating substances and mixtures Not classified - - - - Nonflammable (Merck (14th, 2006))
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - The substance contains sodium in the molecule. However, there is no data available.
13 Oxidizing liquids Not applicable - - - - Solid (room temperature)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. As relevant information, it is described that its solution corrodes brass, zinc, and copper (HSDB (2003)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The classification was made based on its LD50 values of 1700 - 1800 mg/kg for rats (EHC 78 (1988)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The classification was made based on its LD50 values of 1300 mg/kg for rabbits (EHC 78 (1988)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (room temperature)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on its LC50 > 6.8 mg/L for rats (OECD Guideline 403) (IUCLID (2000)), the substance was classified into "Not classified" (Category 5 or Not classified in UN GHS). As relevant information, since its saturated vapour concentration is 3.15*10(-6) mg/L, test animals were presumably exposed to dust.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		As a result of a test using rabbits (according to OECD Guideline 404), the substance is described to be irritating (IUCLID (2000)). Also, in another test in which undiluted test substance was applied to the skin of rabbits for 24 hours, erythema and edema were observed throughout the observation period (seven days), the substance was determined to be moderately irritating (IUCLID (2000)). Based on the above test results, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In a test in which the test substance was applied to the conjunctival sac of rabbits, it is reported to be not irritating (IUCLID (2000)). However, in another test using rabbits, application lead to slight erythema after 24 hours, but there were no findings one week after application, therefore, the substance was determined to be slightly irritating (IUCLID (2000)). Based on the result, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In a skin sensitization test using guinea pigs (Buehler test), the substance was positive (IUCLID (2000)). And it is rated R43 in the EU classification (EU-Annex 1 (accessed in August 2008)). Therefore, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - In a chromosomal aberration test using bone marrow cells of orally administered Chinese hamsters (in vivo mutagenicity test using somatic cells), the substance was negative (IUCLID (2000)). As relevant information, as for in vitro tests, an Ames test and a HGPRT assay showed negative results (IUCLID (2000)), and a chromosomal aberration test indicated positive results (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		A two generation oral exposed reproductive test using rats caused decreased body weight gain and reduced feed consumption, but no effects on fertility or born offsprings (IUCLID (2000)). However, in a developmental test in which rats and rabbits were orally administered during the organogenetic period, developing meningocele due to which suspicions are raised about the effects of the test substance (IUCLID (2000)), especially in rabbits, the number of dead implantations markedly increased and the number of live fetuses decreased, post-implantation loss also increased, and at the same doses, diminished body weight gain and reduced feed consumption were observed (IUCLID (2000). Therefore, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (blood), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (blood)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		As symptoms after oral administration to rats and cats, cyanosis and dyspnoea were observed, and since formation of methemoglobin in rats (the content is 42.2%, LD50 = 1.21 mL/kg) was described to be 3 - 7%, and in cats, 20 - 50% 4 - 6 hours after application of LD0 = 90 mg/kg, the substance was classified into Category 2 (blood). In addition, since it is described that after inhalation exposure to rats (according to OECD Guideline 403), animals showed discharge from the nose and eyes, respiratory sounds could be heard, indicating irritation of the respiratory tract, the substance was classified into Category 3 (respiratory tract irritation). (Notes) Based on results of the oral administration test using cats, the substance should be classified into Category 1. However, since these are List 2 data and do not satisfy the Classification criteria 1b 3), according to this guidance, the substance was classified into Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - After repeated inhalation to rats 4 hours daily for 3 weeks, at the dose of 1.54 mg/L or more, as histopathological changes in the lung, emphysema and multiple pulmonary lesions developed, at the dose of 4.53 mg/L, death as well as such as tracheitis, thymic atrophy, and hyperplasia were observed (IUCLID (2000)). However, since all of these effects developed at doses above the guidance values, and the effects at cut off values are not known, classification is not possible. Still other oral administration tests or percutaneous administration tests using rats had been performed (IUCLID (2000)). However, their doses were not appropriate for classification.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its LC50 = 0.175 mg/L (measured value) for fish (bluegills) (IUCLID (2000)), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its preexisting classification for acute toxicity is Category 1, and it is expected not to be rapidly degradable (SRC, BioWin V4.10), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information