GHS Classification Result

Chemical Name：tert-butyl acetate
CAS：540-88-5

Result：
ID: 20A2117
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since its flash point is below 23degC (HSDB (2005)) and its initial boiling point is above 35degC (Merck (14th, 2006)), the substance was classified into Category 2.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 425degC (HSDB (2005)), which is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Its rat LD50 of 3420 mg/kg, male LD50 of 4100 mg/kg, female LD50 of 4750 mg/kg (all from CICAD 64 (2005)) and its rat LD50 of 3300 mg/kg (DFGOT vol. 19 (2003)) are equivalent to the guidance value of Not classified in JIS classification (Category 5 of UN classification).
1 Acute toxicity （Dermal） Not classified - - - - Since it is documented that no mortality was found in rabbits following 24h exposure at 2000 mg/kg (CICAD 64 (2004)), and no overt toxicity was observed following 24h exposure at approx. 1800 - 20700 mg/kg (CICAD 64 (2004)), the substance was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Its documented rat LC50 value of 13.3 mg/L (4h exposure) (equivalent to 2800 ppmV of gas) (CICAD 64 (2005); DFGOT vol. 19 (2003)), and its rat LC50 value of 20 mg/L (6h exposure) (4h conversion, 24.6 mg/L; equivalent to 5000 ppmV of gas) (CICAD 64 (2005) are equivalent to the guidance value of Category 4. As relevant information, since the two LC50 values are less than 90% of the saturated vapour pressure concentration (61842 ppmV), the substance is considered to have been tested with "vapour with almost no included mists" (evaluated values of the gas were used).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In a Draize test using rabbits, the substance was applied for four hours, and 24 hours later, for 4 of 6 animals the score was 1, which recovered in 48 hours (CICAD 64 (2005)). Furthermore, in another test using multiple rabbits, no signs except for erythema were observed for 24 hours. Therefore, the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In a test using rabbits, mean Draize score at 1, 24, 48, and 72 h was 14.5, 6.8, 2.0, and 0, respectively. And each sign of corneal opacity, iritis, and conjunctival irritation were cleared by day 3 to day 7 (CICAD 64 (2005)). Therefore, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - It is documented that in a micronucleus test using erythrocytes in rats after inhalation exposure (for six hours) (in vivo mutagenicity test using somatic cells), the substance was negative (CICAD 64 (2005)). However, since there is no data of somatic cell or germ cell in in vivo genotoxicity tests with another route, and due to the lack of information, the substance was classified into "Classification not possible". As relevant information, it is reported that in in vitro tests (Ames test, chromosomal aberration test), the substance was negative (CICAD 64 (2005)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In an oral administration test using rats, at doses of 2000 mg/kg or more, which caused mortality, clinical signs including ataxia, flaccid muscle tone, lethargy, dyspnoea, loss of righting reflex, piloerection, tremors, and coma were observed, but no tissue or organ changes were observed in the surviving animals (CICAD 64 (2005)). Also, in an inhalation exposure test using rats, at doses of 13.4 mg/L (four-hour conversion) or more, which caused mortality, inactivity and lethargy were observed, but no tissue or organ changes were observed in the surviving animals (CICAD 64 (2005)). Furthermore, in another inhalation exposure test using rats, clinical signs including inactivity, sedation, anesthesia, and lethargy were observed (CICAD 64 (2005)). Based on the above descriptions, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a rat 14-day inhalation exposure test, at the dose equivalent to the guidance value of Category 2, centrilobular hypertrophy of hepatocytes and hyaline droplet degeneration in males were observed. However, since there is no other data available, and due to the lack of data, classification is not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Based on its 96h-LC50 = 327 mg/L for fish (fathead minnow) (Aquire (2008)), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since the substance is water soluble (water solubility, 8333 mg/L (PHYSPROP Database (2008)) and its preexisting classification for acute toxicity is "Not classified", it was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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