GHS Classification Result

Chemical Name:potassium cyanate
CAS:590-28-3

Result:
ID: 20A2122
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - There are chemical groups (cyanates) present in the molecule associated with self-reactive properties. However, since no other information is available, classification is not possible.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - The chemical structure of the substance contains metals (K). However, no other data are available.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on its two reported rat LD50 values (2360 mg/kg and 567 mg/kg) and some information (its rat LD50 <= 1000 mg/kg) (PATTY (5th, 2001)), the substance was classified into Category 4. As relevant information, the substance is rated R22 in the EU classification.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Since in a skin irritation test using rabbits (according to OECD TG 404), the substance was not irritating (IUCLID (2000)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In an eye irritation test using rabbits (in compliant with OECD TG 405), the mean scores across 24, 48, and 72 h post application were 2 or higher in all 3 treated rabbits for conjunctival redness and 2 or higher in 2 out of 3 rabbits for chemosis. The maximum mean total score was 31.3 (maximum value: 110) (ECETOC TR 48 (1998); IUCLID (2000)). It is described that as a result, the substance was determined to be irritating, and some findings were present till the end of the three-week observation period (IUCLID (2000)). Based on above, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Since there is no in vivo data available, classification is not possible. As relevant information, as for in vitro tests, negative results in an Ames test, and positive results in a chromosomal aberration test using CHO cells are reported (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
It is documented that its rat LD50 value for oral administration was 567 mg/kg, and as clinical signs after administration, such as sedation, catalepsy, lateral and dorsal position, loss of righting reflex, coordination disturbances, tremors, and clonic convulsions were reported (IUCLID (2000)). However, at a dose of 464 mg/kg, no toxicological signs were reported (IUCLID (2000)). The above specific signs suggested effects on the nervous system, and although the doses were near the lethal dosage, signs showing effects on the nervous system were found, and the doses were below the guidance values. Therefore, the substance was classified into Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 96h-LC50 = 12.5 mg/L for fish (rainbow trout) (ECOTOX, 2008), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its preexisting classification for acute toxicity is Category 3, and it is not rapidly degradable (SRC, BioWin V4.10), the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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