GHS Classification Result

Chemical Name:2-methylbutyl acetate
CAS:624-41-9

Result:
ID: 20A2125
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point is 35degC (GESTIS (accessed in August 2008)), the substance was classified into Category 3.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - The test results available are solely that of a mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) (DFGOT vol. 11 (1998)). Therefore, classification is not possible. The rat LD50 of the mixture for males > 14000 mg/kg, and for females > 12000 mg/kg (DFGOTvol. 11 (1998)).
1 Acute toxicity (Dermal) Classification not possible - - - - The test results available are solely that of a mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) (DFGOTvol. 11 (1998)). Therefore, classification is not possible. The rabbit LD50 of the mixture for males > 8300 mg/kg, and for females > 1400 mg/kg (DFGOTvol. 11 (1998)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - The test results available are solely that of a mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) (DFGOTvol. 11 (1998)). Therefore, classification is not possible. As relevant information, the mixture produced moderate erythema and mild oedema, and they still persisted 7 days later (DFGOTvol. 11 (1998)).
3 Serious eye damage/eye irritation Classification not possible - - - - The test results available are solely that of a mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) (DFGOTvol. 11 (1998)). Therefore, classification is not possible. The mixture produced mild irritation which had regressed completely 7 days later (DFGOTvol. 11 (1998)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - The test results available are solely that of a mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) (DFGOTvol. 11 (1998)). Therefore, classification is not possible. As relevant information, the mixture produced mild skin sensitization (DFGOTvol. 11 (1998)).
5 Germ cell mutagenicity Classification not possible - - - - Since there are no available in vivo test results, and also there are no available in vitro mutagenicity test results with multiple indices, classification is not possible. As relevant information, in in-vitro mutagenicity tests (Ames test, mutagenicity test using CHO cells), the mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) was negative (DFGOT vol. 11 (1998)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - The test results available are solely that of a mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) (ACGIH (2001)). Therefore, classification is not possible. As relevant information, there was an increased incidence of skeletal malformations in fetuses (ACGIH (2001)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - The test results available are solely that of a mixture (65% n-pentyl acetate and 35% 2-methylbutyl acetate) (DFGOTvol. 11 (1998)). Therefore, classification is not possible. As relevant information, in a guinea pig inhalation test (for six hours), at the dose equivalent to the guidance value of Category 2, the mixture caused laboured breathing, ataxia, and loss of righting reflex (DFGOTvol. 11 (1998)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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