GHS Classification Result

Chemical Name：methoxyacetic acid
CAS：625-45-6

Result：
ID: 20A2126
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - In all test methods, its flash point was 110degC or more.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Its rat LD50 value of 1000 - 1500 mg/kg (ECETOC TR95 vol. 2 (2005)) is equivalent to the guidance value of Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - There were no mortalities detected following exposure for 7 hours to a vapour saturated atmosphere at 20degC (6.55 mg/L; 4 h conversion, 7.86 mg/L) (ECETOC TR95 vol. 2 (2005)). However, classification is not possible based only on this data.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is documented that the substance was corrosive to rabbit skin (ECETOC TR95 vol. 2 (1995)), its pH value was 1.6 (100 g/L) (GESTIS (accessed in August 2008)), and it is rated R34 in the EU classification, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since its pH value was 1.6 (100 g/L) (GESTIS (accessed in August 2008)), and it is documented that the substance was corrosive to rabbit skin (ECETOC TR95 vol. 2 (1995)), the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Since there is no available in vivo mutagenicity test data, and also there is no available in vitro mutagenicity test data with multiple indices, classification is not possible.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a 2-generation continuous breeding test in which mice received the substance via drinking water, parental body weight and fertility index were reduced, and in high-dose groups in the F1 generation, no animal became pregnant, and at the two lower dose levels, the number of litters per pair and the number of viable animals per litter were severely reduced (ECETOC TR95 vol. 2 (2005)). Also, in many tests in which animals orally received the substance during the organogenetic period, an increase in the number of resorptions and of malformed fetuses was noted, and in rats, hydronephrosis, limb and cardiac malformations, and in mice, digit and paw malformations have been reported (ECETOC TR95 vol. 2 (2005)). Furthermore, after oral exposure in male rats, testicular atrophy, damage, and loss of spermatocytes were seen (ECETOC TR95 vol. 2 (2005)). On the other hand, in humans, multiple epidemiological studies reported abortion and fetal malformations (ECETOC TR95 vol. 2 (2005)). Since, as described above, animal tests have obviously showed effects on parental fertility and development of fetuses, and also in humans, suggested adverse effects on the development of children, the substance was classified into Category 1B. As relevant information, the substance is rated R61-62, classified into Category 2 in the EU classification.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on that in a rat oral administration test, at doses of 1000 and 1500 mg/kg bw (LD50 values) equivalent to the guidance values of Category 2, central nervous symptoms (convulsions, paresis, and atonia) were reported (ECETOC TR95 vol. 2 (2005)), the substance was classified into Category 2 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information