GHS Classification Result

Chemical Name：EPTC (ISO); S-ethyl dipropylthiocarbamate
CAS：759-94-4

Result：
ID: 20A2128
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 116degC (ICSC (1996); HSDB (2003)), which is above 110degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Of its rat LD50 values of 1630 mg/kg (EHC, No. 76, 1988) and 2550 mg/kg (male) (EHC, No. 76, 1988), the former one, which indicates the larger hazard, was used for the basis to classify the substance into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on its rat LD50 values of 3200 mg/kg (EHC, No. 76, 1988) and 3200 mg/kg (HSDB (2003)) documented, the substance was classified into "Not classified" in JIS classification (Category 5 in UN classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Since there is no available in vivo mutagenicity test data, and also there is no available in vitro mutagenicity test data with multiple indices, classification is not possible. As relevant information, it is described that the substance is negative in an Ames test (in vitro mutagenicity test).
6 Carcinogenicity Classification not possible - - - - The data of a rat two-year feeding test are documented (IRIS (2002)). However, since the report does not provide details of the test or test results, and due to the lack of data, classification is not possible.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a two-generation reproduction test using rats fed the substance, parental toxicity consisted of reduced body weight and dose-related increased incidence of cardiomyopathy, and fetal toxicity consisted of reduced body weight (IRIS (2002)). In a developmental test using rats and rabbits, fetal teratogenicity was not observed, but at doses above the rat parental LEL, increased resorption was found. Therefore, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Some workers who experienced air levels of the herbicide in the working zone ranging from 135 to 210 mg/m3 reported headache and nausea (EHC (1988)). However, this datum is not sufficient, and classification is not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It is documented that in a rat subchronic feeding test, females had depressed brain cholinesterase activity (IRIS (2002)). However, since the test does not provide fundamental information such as the administration period and the administration amounts, and due to the lack of data, classification is not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 48h-LC50 = 6.4 mg/L for crustaceans (Daphinia magna) (Aquire (2008)), the substance was classified into Category 2.
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its preexisting classification for acute toxicity is Category 2, and it is not rapidly degradable (SRC, BioWin V4.10), the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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