GHS Classification Result

Chemical Name：C.I. Solvent Yellow 14; 1-phenylazo-2-naphthol
CAS：842-07-9

Result：
ID: 20A2129
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - The substance is rated R43 in the EU classification. However, since there is no other data available, and due to the lack of data, classification is not possible.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is documented that in a chromosomal aberration test using mouse bone marrow cells after intraperitoneal administration, the substance was negative, and in a micronucleus test using mouse bone marrow cells after intraperitoneal administration, the substance could not be determined to be negative or positive (both are in vivo mutagenicity tests using somatic cells) (NTP DB (accessed in September 2008)). However, since it is reported that in a rat micronucleus test with oral administration (in vivo mutagenicity test using somatic cells), the substance was positive, and in a micronucleus test using rat and mouse bone marrow cells, the substance was positive (Mutagenesis, 12, 225-228 (1997)), it was classified into Category 2. As relevant information, it is documented that in a SEC test using mouse bone marrow cells after intraperitoneal administration (in vivo genotoxicity tests using somatic cells), the substance was positive (NTP DB (accessed in September 2008)), in both of a Ames test and a mouse lymphoma assay (both is an in vitro mutagenicity test), the substance was positive (NTP DB (accessed in September 2008)).
6 Carcinogenicity Not classified - - - - Since the substance is rated Group 3 by the IARC (IARC Vol. 8 (1975)), it was classified into "Not classified". As relevant information, in a 103-week feeding test using mice and rats, the carcinogenicity was not determined in mice, but the increased incidence of hepatic tumors in rats was found (NTP TR-226 (1982)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a 13-week mixed diet test using mice, at the dose of 600 mg/kg being above the guidance value, necrosis and regeneration of the renal cortical tubular epithelium and lymphoid depletion of the thymus were observed (NTP TR-226 (1982)). In a 13-week mixed-diet test using rats, at a dose of 200 mg/kg, which is above the guidance value, hepatic degeneration was observed (NTP TR-226 (1982)), and at the doses of 25 and 50 mg/kg, which are within the Category 2 guidance values, pigment deposition in the tubular epithelium of the kidney cortex was observed (NTP TR-226 (1982)). Since it is described that in males, the pigment deposition was associated with nephrosis (NTP TR-226 (1982)), and in mice, also at doses above the guidance value range, necrosis and regeneration of the renal cortical tubular epithelium were detected, the substance was classified into Category 2 (kidney).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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