Chemical Name：1-ethoxypropan-2-ol; 2PG1EE; 1-ethoxy-2-propanol; propylene glycol monoethyl ether;
CAS：1569-02-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3		Warning	H226: Flammable liquid and vapour	P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	It is rated UNRTDG 3 III, and its flashing point is 43degC (closed cup) (IUCLID (2000)), which is >= 23degC and <= 60degC.
7	Flammable solid	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	-	-	-	-	Its autoignition point is 225degC (IUCLID (2000)), which is above 70degC.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	The substance contains oxygen which is chemically bonded only to carbon.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Since its rat LD50 > 5000 mg/kg (ECETOC TR095 vol. 1, 2 (2005)), the substance was classified into "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Since its rabbit LD50 = 9 mL/kg (8100 mg/kg) (ECETOC TR095 vol. 1, 2 (2005)), the substance was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	It is documented that there is no rat mortality following exposure to 2,213 ppm (9,590 mg/L/4h) (ECETOC TR095 vol. 1, 2 (2005)). Classification is not possible based on this datum only. As relevant information, since its saturated vapour pressure concentration is 5100 ppm, the substance was considered as vapour with almost no included mists.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Since it is documented that there is no rat mortality following exposure to 43 mg/L (10000 ppm) (ECETOC TR095 vol. 1, 2 (2005)), the substance was classified into "Not classified". As relevant information, since its saturated vapour pressure concentration is 21 mg/L/4h (5100 ppm), the experiment was presumably carried out in a mist state.
2	Skin corrosion/irritation	Not classified	-	-	-	-	Since it is documented that in tests using rabbits, the substance was mildly irritant to rabbit skin (Draize score, 1.63) (ECETOC TR095 vol. 1, 2 (2005)), or the substance was slightly irritating (IUCLID (2000)), it was classified into "Not classified" in JIS classification (Category 3 in UN classification).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	In a test using rabbits, the substance was found to be a mild irritant, not a severe irritant, to rabbit eyes causing only conjunctival irritation and corneal reaction, and the effects were fully reversible within seven days (ECETOC TR095 vol. 1, 2 (2005)). In addition, in Draize tests using rabbits, the substance was not irritating or moderately irritating (IUCLID (2000)). Based on the evaluation results of ECETOC being in List 1, the substance was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Since there are no in vivo test data or multi-index in vitro mutagenicity positive results available, classification is not possible. As relevant information, all results of an Ames test and a chromasomal aberration test using cultured human lymphocytes (both were in vivo mutagenicity tests) were negative (ECETOC TR095 vol. 1, 2 (2005)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	It is reported that in an inhalation test using rats and rabbits during the organogenetic period, at doses that showed maternal reduced body weight gain, there was no evidence of any effects on fetal development (ECETOC TR095 vol. 2 (2005)). However, since there is no data on maternal sexual functions or fertility, and due to the lack of data, the substance was classified into "Classification not possible".
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects, Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	It is reported that a mouse, a guinea pig, and a rabbit tolerated up to 7000 ppm for 1h (conversion, 7.46 mg/L/4h) without any effects other than irritation of the eyes and respiractory tract. A 2-h exposure caused more severe irritation (PATTY (5th, 2001)). All five rats exposed for 4h to a concentration calculated to be 10,000 ppm (conversion, 42.6 mg/L/4h) survived, but they showed signs of marked irritation to the eyes and nose, and were anesthetized by the end of the exposure period (PATTY (5th, 2001)). While, in rat oral administration, at doses of 5000 mg/kg or more, above the guidance value of Category 2, anesthetic action was noted. Therefore, the substance was classified into Category 3 (narcotic effects, respiratory tract irritation). As relevant information, it is documented that in rabbit inhalation exposure, at a dose equivalent to the guidance value of Category 2, rabbits showed albuminuria and red cells in urine, and in a rat oral administration test, at doses above the guidance value of Category 2, effects on the kidney were observed (PATTY (5th, 2001)). However, since effects on the kidney were considered to be slight, within the range of guidance values, these data were not evaluated.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	It is documented that in a 13-week inhalation exposure test using rats (6h/day, 5 days/week; doses, 100, 300, 2000 ppm (0.426, 1.266, 8.36 mg/L)), there was evidence of a slight increase in liver weight when exposed to the highest concentration, but no other effects were noted, and the test specified 1.266 mg/L as NOEC (ECETOC TR064 (1995)). The substance should be classified into "Not classified" (inhalation), but due to a lack of information on other routes, it was classified into "Classification not possible".
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.