Chemical Name:di-allate (ISO); S-(2,3-dichloroallyl)-N,N-diisopropylthiocarbamate
CAS:2303-16-4
ID: | 20A2133 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2008 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Solid (GHS definition). However, since its melting point is near room temperature, technically, it is dealt with as a liquid. Since its flash point is 77degC (HSDB), the substance was classified into Category 4. |
7 | Flammable solid | Not classified | - | - | - | - | Since its flash point is 77degC (HSDB (2003)), the substance was classified into "Not classified". |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Since its melting point is 25degC, and test methods applicable to solid (melting point <= 140degC) substances are not available, classification is not possible. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Its rat LD50 values of 393 - 1000 mg/kg (IARC vol. 30 (1983)) are within the guidance values of Category 4. | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on its rabbit LD50 = 2000 - 2500 mg/kg (EHC 76 (1988), IARC vol. 30 (1983)), the substance was classified into "Not classified" in JIS classification (equivalent to Category 5 in UN classification). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
Since it was documented that in a test using rabbits, the substance is a moderate irritant to the skin (EHC 76 (1988): The pesticide manual: world compendium, 7th ed., Croydon, British Crop Protection Council), and also in human exposure, its irritation was suggested (HSFS (2004), HSDB (2003)), the substance was classified into Category 2. | |
3 | Serious eye damage/eye irritation | Category 2 | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Since it was documented that in a test using rabbits, the substance is a moderate irritant to the skin (EHC 76 (1988): The pesticide manual: world compendium, 7th ed., Croydon, British Crop Protection Council), and also in human exposure, its irritation was suggested (HSFS (2004)), the substance was classified into Category 2. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification is not possible, due to a lack of in vivo test data. As relevant information, some in vitro mutagenicity tests (Ames test (EHC 76 (1988)), a mutagenicity test using mammalian cells (IARC (vol.30, 1983)), and a chromosomal aberration test using mammalian cells (IARC vol.30) indicated positive results. |
6 | Carcinogenicity | Not classified | - | - | - | - | Since the substance is rated Group 3 in IARC (IARC Suppl. 7 (1987)), it was classified into "Not classified". |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | It is documented that in a test using rabbits, the substance did not show any teratogenicity (Birth Defects 3rd (2000)). However, since there is no other data available, classification is not possible. |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | It is reported that in a rat oral administration test, its effects on the nervous system occurred at high dose levels tested (IARC (vo.12, 1976), EHC 76 (1988)). However, due to a lack of data, the substance was classified into "Classification not possible". |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | It is documented that in a 90-day oral administration (diet) test using rats, at the dose of 8 mg/kg/day, irritability, hyperactivity, and mild cardiac changes occurred (EHC 76 (1988)). However, since there is no other data available, classification is not possible. |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Since its 96h-LC50 = 5.9 mg/L for fish (bluegills) (EHC 78 (1988)), the substance was classified into Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Its preexisting classification for acute toxicity is Category 2, it is not rapidly biodegradable (SRC: BioWin V4.10) and it is estimated to have high bioconcentration potency (log Pow = 4.49, PHYSPROP Database (2008)), and therefore, the substance was classified into Category 2. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |