GHS Classification Result

Chemical Name：dibromomethane
CAS：74-95-3

Result：
ID: 20A2141
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Nonflammable (Hommel (1996)).
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Nonflammable (Hommel (1996)).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Nonflammable (Hommel (1996)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - It is documented that its rat LD50 > 1000 mg/kg (PATTY (5th, 2001)), which is equivalent to the guidance values of Category 4 or "Not classified". However, the original literature is not published. It is reported that its rat LD50 = 108 mg/kg (RTECS (2008)), but the value is significantly different from that in PATTY. Since there is no other data available, and due to the lack of data, the substance was classified into "Classification not possible".
1 Acute toxicity （Dermal） Classification not possible - - - - It is documented that its rabbit LD50 > 400 mg/kg in RTECS in the List 3. Since there is no other data available, classification is not possible.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on its rat LC50 (2h) = 40000 mg/m3 = 40 mg/L (4h-conversion, 28.3 mg/kg) (HSDB (2008)), the substance was classified into "Not classified" in JIS classification (Category 5 in UN classification). As relevant information, since its saturated vapour pressure concentration is about 41.5 mg/L, the substance was considered as vapour with included mists, and the cut off values for vapour were used.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - It is documented that in an Ames test, the substance was positive. However, since no in vivo test data are available, classification is not possible.
6 Carcinogenicity Classification not possible - - - - It is documented that 100 male rats (15 male rats and 15 female rats were exposed for 13 weeks, necropsied, and examined) were exposed to the substance vapor for 2 years in an oncological study and no oncological changes related to exposure were observed (PATTY (5th, 2001)). However, since the test is limited to male rats, and does not provide data on animal species other than rats, due to the lack of data, the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is documented that when an essentially saturated atmosphere (415 mg/L) was inhaled by rats, anesthesia occurred in 3 minutes, with 50% mortality in 18 minutes (PATTY (5th, 2001)), a vapor concentration of 17 - 20 mg/L (2400 - 2800 ppm), causing "disorders in the central nervous system" (the duration of the exposure and other details were not stated) (PATTY (5th, 2001)), and the substance exerts CNS depression (HSDB (2008)). Therefore, the substance is considered to have effects on the central nervous system. However, due to a lack of data, classification is not possible. Since exposure to the substance in a vaporous state induced narcotic effects followed by death as documented by PATTY, the substance was classified into Category 3 (narcotic effects). In addition, as for liver and kidney disorder, PATTY (5th, 2001) and HSDB (2008) have descriptions, but they do not provide specific data. Therefore, due to the lack of data, classifications for the liver and kidney are not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a limited study in which rats and rabbits were exposed for 114 days to 200 ppm (1.42 mg/L), which is over the guidance value of Category 2, the weights of the livers of male rats were elevated when compared to the controls, and histological changes were found in the livers and kidneys of rats and rabbits, but the lower limit of the toxic dose is unknown (PATTY (5th, 2001)). In addition, when inhaled 4h/day for 2 months, 0.25 mg/L (90-day, 6h/day conversion, 0.11 mg/L), which is equivalent to the guidance value of Category 1, it was reported to cause disorder in the kidneys and livers, but the animal species were not stated (PATTY (5th, 2001)). Therefore, due to the lack of data, the substance was classified into "Classification not possible". As relevant information, in a very limited study, the substance was administered orally to rabbits, and the treatment with >= 400 mg/kg produced marked anesthesia (PATTY (5th, 2001)), which was much over the cutoff value (100 mg/kg/day) of the range of guidance values.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information