GHS Classification Result

Chemical Name：1-naphtol
CAS：90-15-3

Result：
ID: 20A2148
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignition point is 541.7degC (HSDB (2006)), which is above 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available. (96degC, Merck (14th, 2006))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Since among its rat LD50 values of 2380 mg/kg (young males) (HSDB (2006)), 1870 mg/kg (old males) (HSDB (2006)), 2590 mg/kg (HSDB (2006)), and 2400 mg/kg (IUCLID (2000)), many of them are equivalent to the guidance value of "Not classified", the substance was classified into "Not classified" in JIS classification (Category 5 in UN classification).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on its rabbit LD = 880 mg/kg (IUCLID (2000)), the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Although it is reported that its rat LC50 > 0.097 mg/L (16.4 ppmV) (HSDB (2006)), classification is not possible only on this datum. As relevant information, since its saturated vapour pressure concentration was 0.36 ppmV, which was below 16.4 ppmV, the substance was considered as mist.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since in a skin dermal irritation test using rabbits, moderate to severe erythem and edema were noted after 72 hours (irritation score of 7.09/8.00) (HSDB (2006)), the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since it is reported that in a test using rabbits, scarring of cornea and conjunctiva was noted (HSDB (2006)), in a rabbit standard Draize test, the substance was severely irritating (RTECS (2006)). Furthermore, it is rated Xi; R41 in the EU classification, therefore, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Since there is no available in vivo test data, and there are no available test results of in vitro mutagenicity tests, classification is not possible.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In a developmental test with oral administration during the organogenetic period of rats, at doses showing parental body weight decrease, no developmental aberration in offspring was observed. But, the test did not provide data on parental sexual functions and fertility. Therefore, due to the lack of data, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (kidney) Warning H371: May cause damage to organs (kidney) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is documented that in an oral administration test using mice, at the dose of 500 mg/kg equivalent to the guidance value of Category 2, in the kidney, degeneration of the distal tubular epithelium, papillary necrosis, and tubular dilation were noted, and in the stomach, there were vascular congestion and acute inflammatory cell infiltration (HSDB (2006)), the substance was classified into Category 2 (kidney). As relevant information, the inflammatory degeneration in the stomach was considered to be caused by irritation of the substance, and was not evaluated.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a rat oral administration test for 13 weeks, at the dose of 400 mg/kg, which is above the guidance value, squamous hyperplasia and hyperkeratosis of the nonglandular stomach were noted, and the NOAEL was 130 mg/kg, which is above the guidance value of Category 2 (HSDB (2006)). However, since there is no other available information for classifying into "Not classified", and due to the lack of data, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 48h-EC50 = 0.73 mg/L for crustaceans (Daphinia magna) (AQUIRE, 2008), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although its preexisting classification for acute toxicity is Category 1, it is rapidly biodegradable (readily biodegradable (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and it is estimated to have low bioaccumulation potency (log Kow = 2.85 (SRC, 2005)), and therefore, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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