GHS Classification Result

Chemical Name:A mixture of: butan-2-one oxime; syn-O,O'-di(butan-2-one oxime)diethoxysilane
CAS:96-29-7

Result:
ID: 20A2151
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point of 58degC (closed cup; Hommel, 1996) or 62degC (closed cup; IUCLID, 2000) falls under Category 3 or 4. Giving precedence to 58degC, the substance was classified into Category 3.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition point of 315degC (IUCLID (2000)) is higher than 70degC, the substance was classified into the "Not classified" category.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - - The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to elements (nitrogen) other than carbon or hydrogen. However, due to lack of data, classification is not possible.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Its rat LD50 is documented to be 930 mg/kg for males, 1620 mg/kg for females, 2326 mg/kg for both sexes, and > 900 mg/kg for both sexes (SIDS (J), accessed in October 2008)). Since Category 4 is most well represented by documented LD50 values (2 of 4 values), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
As a result of rabbit tests, LD0 and LD100 were found to be 1000 and 1800 mg/kg, respectively (SIDS (J), accessed in October 2008). From these results, LD50 is estimated to be within the range of Category 4. Thus, the substance was classified into Category 4.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Since its rat LC50 = 20 mg/L/4h (IUCLID, 2000: Federal register USA (1986) 51, 220, 41430-41432), the substance was classified into the "Not classified" category.
2 Skin corrosion/irritation Not classified - - - - Draize tests using rabbits found that the substance is slightly irritating, and the tests using rabbits found that it is moderately irritating (slightly irritating), presumably following the USA guidelines. Based on these results as well as expert judgement, the substance was classified into the "Not classified" category using the JIS classification criteria (Category 3 in the United Nations classification).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Several rabbit tests found that the substance is irritating to highly irritating (IUCLID, 2000). Thus, it was classified into Category 2A. Its EU Risk Phrase is Xi; R41 (EU-Annex 1, accessed in September 2008).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Guinea pig maximization tests (OECD guidelines 406) found that the substance is skin sensitizing (IUCLID, 2000). In addition, it is rated as Xi; R43 in the EU classification. Thus, it was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on negative results acquired in two in vivo mutagenicity tests using somatic cells: micronucleus bone marrow and peripheral blood studies using mice that underwent oral administration (NTP DB, accessed in September 2008) and chromosomal aberration tests using bone marrow cells of rats that underwent oral administration (IUCLID (2000)), the substance was classified into the "Not classified" category. Regarding in vitro mutagenicity tests, generally negative results have been reported in chromosomal aberration tests using CHL cells (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council, accessed in September 2008), NTP TOX-51), Ames tests (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008), and mouse lymphoma assays (accessed in October 2008).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In 2-year inhalation tests using rats, there was an increased incidence of hepatocellular carcinoma and adenoma in male rats. In similar tests using mice, there was an increased incidence of liver cancer in male mice (IUCLID, 2000). Moreover, the substance is rated as Category 3 in the EU's carcinogenicity evaluation. Thus, the substance was classified into Category 2.
7 Reproductive toxicity Not classified - - - - In OECD preliminary reproductive toxicity screening tests using rats that underwent oral administration, there were no effects of administration on coitus ability, fertility, and estrous cycles in the highest dose (100 mg/kg) groups, although a decreased delivery rate was seen; in addition, birth and growth of offspring were not affected either (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008). Similarly, in rat two-generation oral administration, no effects of administration related to reproduction or birth were detected (SIDS (J), accessed in October 2008). Also, in oral administration tests conducted during the organogenetic period using rats or rabbits, the substance was found to be not developmentally toxic or teratogenic (IUCLID (2000)). As a result of exposure to the test substance in the tests mentioned above, there were no adverse effects on sexual functions and fertility of parental animals, and development of offspring. Thus, the substance was classified into the "Not classified" category.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 1 (hematopoietic system) Danger H372: Cause damage to organs through prolonged or repeated exposure (hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In rats that underwent repeated oral exposure, the following were detected at 20 mg/kg/day (90-day correction: 6.2 mg/kg/day) or higher concentration exposure for 28 days: decreased erythrocytes, hematocrit value, and hemoglobin concentration, liver Kupffer cell hypertrophy and hemosiderin phagocytosis, blood congestion in the spleen, increased extramedullary hematopoiesis, and increased hemosiderin granules (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008). In addition, 13-week administration of 50-65 mg/kg/day or above showed effects such as hematopoietic cell proliferation in the spleen, hematopoietic cell proliferation in the bone marrow, liver Kupffer cell erythrophagocytosis and hemosiderin pigmentation, and renal tubule hemosiderin pigmentation (NTP TOX-51 (1999)). Also, similar effects of the substance including those on hematological indices were noted in rats that underwent inhalation exposure (IUCLID (2000)), and mild effects on hematological indices were detected in repeated oral or inhalation exposure tests using mice (NTP TOX-51 (1999), IUCLID (2000)). Overall, these documented studies indicated that repeated exposure causes characteristic changes in the hematopoietic system, and changes caused through oral route occurred at concentrations that fall under Category 1 guidance values while changes caused through inhalation route occurred at concentrations that fall under Category 2 guidance values. As such, the substance was classified into Category 1 (hematopoietic system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 72-hour EC50 = 16 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2001), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Its classification for acute toxicity is Category 3 and it is not rapidly degradable (non-biodegradable, BOD degradability: 24.7% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1982)). However, since its 72-hour NOEC = 2.6 mg/L (> 1 mg/L) for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2001), the substance was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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