GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：alpha,alpha,alpha-trifluorotoluene; benzotrifluoride
CAS：98-08-8
Result：
| ID: | 20A2154 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point is 12degC (HSDB (2003)) and its initial boiling point is 103.46degC (Howard (1997)), the substance was classified into Category 2. |
| 7 | Flammable solid | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Its autoignition point is 620degC (NFPA (13th, 2006)), which is above 70degC. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | It is a compound containing fluorine (but not oxygen or chlorine), which is bonded only to carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Since its rat LD50 = 15000 mg/kg (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008), the substance was classified into the "Not classified" category. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on its rat LD50 of > 2000 mg/kg (IUCLID, 2000), the substance was classified into the "Not classified" category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Since its rat LC50 = 70.81 mg/L (11825 ppmV) (IUCLID, 2000), the substance was classified into Category 4. As its saturated vapour concentration is 305.3 mg/L, we figured that the study was conducted in a vapour state with almost no included mists. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | Rabbit tests (OECD TG 405) found that the substance is not irritating (IUCLID (2000)). Based on this document, the substance was classified into the "Not classified" category. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification is not possible due to lack of in vivo test results as well as positive results in in vitro mutagenicity tests using several indices. As additional notes, most Ames tests conducted gave negative results (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008; IUCLID (2000)) and chromosomal aberration tests using CHL/IU cells yielded negative results (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In reproductive toxicity tests using rats, no effects of the substance on sexual functions and fertility were noted in parental animals; and in offspring, no external abnormalities were detected while suppressed body weight gain was noted (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in September 2008). These reports, however, provide insufficient information regarding developmental toxicity to offspring. Thus, classification is not possible due to insufficient data available. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In 2-week oral administration tests using rats, the following effects were observed at 100 mg/kg (90-day conversion: 15.5 mg/kg) or higher doses, which fall under Category 2 guidance values: centrilobular hepatocyte hypertrophy in both sexes; appearance of hyaline droplets in the proximal renal tubular epithelium in male rats; and necrosis, basophilic change, and dilatation of the proximal renal tubule. As we considered the appearance of hyaline droplets, and necrosis and dilatation of the proximal renal tubule as male specific responses, and there are no other studies available, the substance was classified into the "Classification not possible" category. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Since its 48-hour EC50 = 3.1 mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2004), the substance was classified into Category 2. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since its classification for acute toxicity is Category 2, and it is not rapidly degradable (non-biodegradable, DO: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1986)), the substance was classified into Category 2. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |