GHS Classification Result

Chemical Name:di-tert-butyl peroxide
CAS:110-05-4

Result:
ID: 20A2169
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point of 18.3degC (Chemical Risk Information Platform (CHRIP), accessed in October 2008) is below 23degC, and its initial boiling point of 109-111degC (Chapman Ver. 16.2, 2008) is above 35degC, the substance was classified into Category 2.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - It is classified as organic peroxide.
9 Pyrophoric liquids Not classified - - - - Its autoignition point at 230degC (Chemical Risk Information Platform (CHRIP), accessed in October 2008) is above 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - - Organic compounds containing oxygen (but not fluorine or chlorine), which forms an O-O bond. Due to lack of additional information, classification is not possible.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Type E Warning H242: Heating may cause a fire P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P410: Protect from sunlight.
P420: Store away from other materials.
P501: Dispose of contents/container to ...
Since it is rated as UNRTDG 5.2, UN 3107, it falls under type E.
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since its rat LD50 is > 25000 mg/kg (DFGOT vol. 3 (1992)), the substance was classified into the "Not classified" category.
1 Acute toxicity (Dermal) Not classified - - - - Since its mouse LD50 is > 10000 mg/kg (PATTY (5th, 2001), the substance was classified into the "Not classified" category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Base on its LC50 of > 4103 ppm (> 24.5 mg/L) documented in 4-hour inhalation using rats (DFGOT vol. 3 (1992)), the substance was classified into the "Not classified" category. Since its saturated vapour concentration is 197 mg/L at 25degC, the study was presumably conducted in a vaporous state.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Since rabbit tests found that the substance is not irritating (DFGOT vol. 3 (1992)), it was classified into the "Not classified" category.
3 Serious eye damage/eye irritation Not classified - - - - Since rabbit tests found that the substance is not irritating (DFGOT vol. 3 (1992)), it was classified into the "Not classified" category.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - The substance was classified into the "Classification not possible" category due to lack of in vivo mutagenicity test results and in vitro mutagenicity test results using several indices. Regarding in vitro mutagenicity tests, Ames tests gave negative results (NTP DB, accessed in October 2008; PATTY, 2001; HSDB, 2003).
6 Carcinogenicity Classification not possible - - - - In mouse tests (administration route not provided), which was continued for more than 19 months, malignant lymphomas were found in 7 animals and pulmonary adenomas were detected in 1 animal out of 35 treated animals (HSDB (2003)). Without other study results, classification is not possible due to insufficient data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 96-hour LC50 is > 1000 mg/L for fish (guppies) (IUCLID 2000), the substance was classified into the "Not classified" category.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Its classification for acute toxicity is the "Not classified" category and its potential for bioaccumulation is presumably low (LogPow = 3.45 (PHYSPROP Database 2008)), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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