GHS Classification Result

Chemical Name:1,3,5-trioxan; trioxymethylene
CAS:110-88-3

Result:
ID: 20A2172
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Category 1 Danger H228: Flammable solid P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
The substance is rated as UNRTDG 4.1 II*ERG 133.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition point of 410degC (Ullmanns (E) (6th, 2003) vol. 15 p.24-27) is above 70degC, the substance was classified into the "Not classified" category.
11 Self-heating substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen, which is bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - Its rat LD50 values of 8190-9500 mg/kg bw (GESTIS (accessed in October 2008)) fall under the "Not classified" category. However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available. Because this substance is easily hydrolyzed to form formaldehyde, see also the classification of formaldehyde (NITE publication ID69 (accessed in January 2009)) in relation to the following discussions on toxicity of this substance.
1 Acute toxicity (Dermal) Classification not possible - - - - Its rabbit LD50 values of > 3980 mg/kg and > 15000 mg/kg (GESTIS (accessed in October 2008)) fall under the "Not classified" category. However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - 4-hour exposure tests using rats have been conducted in which doses of 6.5 mg/L (1523 ppm) and 26 mg/L (7072 ppm), which are above Category 3 values, were tested (GESTIC (accessed in October 2008)); but since mortality and LC50 information is not provided, classification was not possible based on this study. Given that its saturated vapour concentration is ca. 23000 ppm or 84 mg/L at 25degC, the study was conducted in a vapour state with almost no included mists.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Rabbit or guinea pig tests (OECD TG 405) found that the substance is not irritating (GESTIS (accessed in October 2008)). However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available.
3 Serious eye damage/eye irritation Classification not possible - - - - Rabbit tests found that the substance is slightly eye irritating (GESTIS (accessed in October 2008). However, no detailed explanations were provided and no other studies are available. Thus, classification is not possible due to insufficient data available. This substance is easily hydrolyzed to form formaldehyde (classification: Category 2A, NITE publication ID69 (accessed in January 2009)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Guinea pig tests (OECD TG 406) found that the substance was not skin sensitizing (GESTIS (accessed in October 2008)). However, these values were obtained using List 3 data, the studies do not provide citations, and no other studies are available. Thus, the substance was classified into the "Classification not possible" category due to insufficient data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo mutagenicity test results and in vitro mutagenicity test results using several indices. Regarding in vitro mutagenicity tests, Ames tests gave negative results (NTP DB (accessed in October 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - There is a study in which developmental toxicity of the substance on the offspring was addressed, but details such as animal species used and test results were not well explained (GESTIS (accessed in October 2008)). Thus, classification is not possible due to insufficient data available.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
In 4-hour inhalation exposure tests using rats, neurological symptoms such as staggering, tremor, and atonia were detected at 26 mg/L which falls under the "Not classified" category guidance values (GESTIS (accessed in October 2008)). Similarly, in 8-hour inhalation exposure tests using rats, neurological symptoms such as staggering, tremor, and atonia were detected at 6.5 mg/L which falls under Category 1 guidance values (GESTIS (accessed in October 2008)). Based on these results, the substance was classified into Category 1 (central nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In 2-week inhalation exposure tests using rats (6 hours/day and 5 days/week), central nervous disturbances and squamous metaplasia with necrosis and desquamation of the nasal mucous membranes were noted at 18.4 mg/L, which is above the guidance doses. In 12-month inhalation exposure tests using rats (5 hours/day and 5 days/week), an increased disturbance of the motor system and reduced activity of the acetylcholineesterase in blood serum were detected at 0.05 mg/L or higher doses, which fall under Category 1 guidance doses (GESTIS (accessed in October 2008)). Based on these results, the substance was classified into Category 1 (central nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 96-hour LC50 is 5950 mg/L for fish (fathead minnow) (AQUIRE, 2008), the substance was classified into the "Not classified" category.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is water soluble (water solubility: 175000 mg/L (SRC, 2005)) and its classification for acute toxicity is "Not classified", the substance was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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