GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,1'-iminodipropan-2-ol; di-isopropanolamine
CAS：110-97-4
Result：
| ID: | 20A2174 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solid | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Its autoignition point is 290degC (Ullmanns (E) (2003)), which is above 70degC. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Its rat LD50 of 4765 mg/kg (PATTY (5th, 2001)) falls under the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Its LD50 of 16000 mg/kg for rats (IUCLID (2000)) and 8000 mg/kg for rabbits (IUCLID (2000)) both fall under "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 2 | Skin corrosion/irritation | Category 1 |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
There are several reports that the application of the substance to abraded or intact sites of rabbit skin caused moderate or slight hyperemia (IUCLID (2000); HSDB (2006)), or the application to abraded sites caused moderate denaturation (IUCLID (2000); HSDB (2006)). Furthermore, in Draize tests using rabbits, application of undiluted test substance to intact sites on the abdomens of rabbits caused irreversible, severe necrosis at several sites (HSDB (2006)). Thus the substance was classified into Category 1. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
In rabbit tests, the substance was found to cause moderate to severe eye irritation (IUCLID (2000)) or chemical burns (IUCLID (2000); HSDB (2006)), and these symptoms underwent spontaneous recovery within 22 days (HSDB (2006)). It is rated as Xi, R36, which falls under Category 2 guidance values. Thus, the substance was classified into Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Not classified | - | - | - | - | In guinea pig tests, the application of the substance caused a weak allergic effect (IUCLID (2000)). On the other hand, In Draize tests in which humans were applied with 2% aqueous solution, no induction of immune response was detected (IUCLID (2000)). In addition, in the study in which sun-protection cream containing 1% diisopropanolamine was applied to 203 volunteers, sensitizing reaction was induced only in one volunteer. Based on these results, the substance was classified into the "Not classified" category (HSDB (2006)). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Since there are no in vivo mutagenicity test results using germ or somatic cells, or no positive results in in vitro mutagenicity tests using several indices, classification is not possible. Both Ames tests (PATTY (5th, 2001); NTP DB (accessed in November 2008)) and chromosomal aberration tests using rat lymphocytes (IUCLID (2000)) gave negative results. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | In 94-week oral administration (mixed diet) tests using rats, no increase in incidences of tumorigenesis was noted (IUCLID (2000)). However, since there are no test data using animals other than rats, classification is not possible due to insufficient data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | In oral administration tests using rats, mice, guinea pigs, or rabbits, hypoactivity and hypothermia were noted (IUCLID (2000)); however, toxic doses were not provided. Thus, classification is not possible due to insufficient data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In the 2-week oral administration study through drinking water using rats (doses: 100, 300, 600, 1200, and 3000 mg/kg), degeneration of kidney was noted at 3000 mg/kg, which fall under the "Not classified" category guidance values (IUCLID (2000)). In 94-week mixed diet administration tests using male rats, no clinical or pathological cases were detected at doses (392-843 mg/kg) above the range of guidance values (IUCLID (2000)); however, this study involved only male rats and one dose. Thus, the substance was classified into "Classification not possible" due to insufficient data available. As additional notes, in 4-week dermal administration tests using rats, no pathological changes were noted other than slight abnormalities found in applied areas with doses that are above the range of guidance values (IUCLID (2000)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Its 96-hour LC50 is > 1000 mg/L for fish (zebra fish), 48-hour EC50 = 277.7 mg/L for crustaceans (Daphnia magna), and 72-hour EC50 = 270 mg/L for algae (Scenedesmus) (IUCLID, 2000). Based on these LC50 values, the substance was classified into the "Not classified" category. |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since it is water soluble (water solubility = 870000 mg/L (PHYSPROP Database, 2008)) and its classification for acute toxicity is the "Not classified" category, the substance was classified into the "Not classified". |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |