Chemical Name：2-(2-hexyloxyethoxy)ethanol; DEGHE; diethylene glycol monohexyl ether; 3,6-dioxa-1-dodecanol; hexyl carbitol; 3,6-dioxadodecan-1-ol
CAS：112-59-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Its rat LD50 values are documented to be 4920 mg/kg (PATTY (5th, 2001)), 4600 mg/kg for male, and 3500 mg/kg for female (PATTY (5th, 2001)). In addition, 3-day LD50 values are reported to be 3016 mg/kg for male and 1823 mg/kg for female (ECETOC TR95 (2005)). Among these five documented values, one 3-day LD50 value is <= 2000 mg/kg, and other four values are above 2000 mg/kg. As such, the substance was classified into the "Not classified" category using the JIS classification criteria (Category 5 in the United Nations classification).
1	Acute toxicity （Dermal）	Category 4		Warning	H312: Harmful in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	The rabbit LD50 values are reported to be 2010 mg/kg for male, 2220 mg/kg for female, and 1410 mg/kg (PATTY (5th, 2001)). Among these values, the value representing the highest toxicity (1410 mg/kg) was used as grounds for classifying the substance into Category 4.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available. Several reports stated that no death case occurred at the saturated vapour exposure. Assuming the vapour pressure to be 0.00118 mmHg at 25degC, the saturated concentration is calculated to be 1.6 ppm or 0.012 mg/L. Since this value is a very low number, it is not a useful reference for acute toxicity classification.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Not classified	-	-	-	-	A sealed application of 0.5 ml of this substance to the skin of rabbits for 4 hours resulted in the development of mild erythema and edemas that were observed for 24 hours (PATTY (5th, 2001)). Based on this report, the substance was classified into the "Not classified" category using the JIS classification criteria (Category 3 in the United Nations classification). It is also reported that an application of 4 ml of this substance for 24 hours resulted in more persisting erythema and edema as well as necrosis (PATTY (5th, 2001)).
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Application of this substance, 0.1 or 0.005 ml, to rabbit eyes resulted in severe corneal or conjunctival damage in all six treated animals, and complete recovery from these damage in 7 to 21 days (PATTY (5th, 2001)). Since the EU Risk Phrase for this substance is R41, and based on the test results that eye damage healed completely within 21 days, the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Negative results have been reported in both micronucleus tests using mouse (both sexes) peripheral blood erythrocytes (PATTY (5th, 2001)) and chromosomal aberration tests using rat (both sexes) bone marrow cells (ECETOC TR95 (2005)). As there are two or more sets of negative results obtained in in vivo mutagenicity tests using somatic cells, the substance was classified into the "Not classified" category. Regarding in vitro tests, while a gene mutation test gave weak positive results (ECETOC TR95 (2005)), an Ames test (ECETOC TR95 (2005)) and sister chromatid exchange test using CHO cells both yielded negative results (PATTY (5th, 2001)).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	The following reports are available: according to a reliable reproduction toxicity test, the substance has no effect on fertility at the dose of 1000 mg/kg/d; most developmental toxicity tests found negative results; and the dose of 1000 mg/kg/d has toxic effects on maternal animals, but not the offspring (SIDS (accessed in February 2009)). Since we cannot verify details of these studies, classification is not possible.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Rabbits were dermally exposed to doses of 100 to 1000 mg/kg nine times during an 11-day period with each application lasted for 6 hours per day. In this study, while signs of irritation were observed, no evidence of systemic toxicity was noted (PATTY (5th, 2001)). Since test details provided are insufficient, classification is not possible.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.