GHS Classification Result

Chemical Name:di(benzothiazol-2-yl) disulphide
CAS:120-78-5

Result:
ID: 20A2183
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignitiion point is >= 365degC (BUA Report No. 126 (1993)).
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Its rat LD50 values are documented to be > 12000 mg/kg (IUCLID (2000)) (BUA Report No. 126 (1993)), 423 mg/kg (BUA Report No. 126 (1993)), > 7940 mg/kg bw (BUA Report No. 126 (1993)), > 7000 mg/kg bw (BUA Report No. 126 (1993)), ca. 7000 mg/kg bw (BUA Report No. 126 (1993)), and > 5000 mg/kg bw (BUA Report No. 126 (1993)). Among these six values documented, all but the value of 423 mg/kg fall under the "Not classified" category. Thus, the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 values of > 7940 mg/kg (IUCLID (2000)) and > 7940 mg/kg (BUA Report No. 126 (1993)), the substance was classified into the "Not classified" category.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on the conclusion that the substance is not irritating in rabbit tests (in compliance with OECD Guidelines 404) (BUA Report No. 126 (1993)), it is classified into the "Not classified" category.
3 Serious eye damage/eye irritation Not classified - - - - Based on the conclusion that the substance is not irritating in rabbit tests (in compliance with OECD Guidelines 405) (BUA Report No. 126 (1993)), it is classified into the "Not classified" category.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
A maximization test (test animal not specified) found that the substance has sensitizing effect (BUA Report No. 126 (1993)). This substance is used as an additive in rubber. In patch tests applying this substance, the following outcomes have been reported: 5 of 21, and 9 of 21 eczema patients showed positive reaction; 17 of 17 allergic patients showed positive reaction while 20 non-allergic patients were tested negative; 25 of 698 allergic patients showed positive reaction; and 50 of 78 male allergic patients (64%), and 33 of 70 female allergic patients (74%) showed positive reaction (BUA Report No. 126 (1993)). In addition, the substance is rated as R43 in the EU classification. Based on this information, it is classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo mutagenicity test results. Regarding in vitro mutagenicity tests, Ames tests and mouse lymphoma assays gave both positive and negative results.
6 Carcinogenicity Classification not possible - - - - 17-month oral administration tests found no increase in incidences of tumorigenesis (BUA Report No. 126 (1993)). However, since there are no study results using other animal species, the substance was classified into the "Classification not possible" category.
7 Reproductive toxicity Classification not possible - - - - In a test conducted earlier in which rats received oral administration during the gestation period, hydrocephaly and hemotomas were detected (BUA Report No. 126 (1993)). However, in a different test conducted later, which fulfilled the current test requirements, no adverse effects on the pre- and postnatal development of offspring were noted (HSDB (2002)). With regard to these contradicting results, an evaluation document stated that the former study has some defects in terms of test procedure and references cited, whereas the latter study meets the current requirements and the negative results obtained in this test are reliable (BUA Report No. 126 (1993)). In addition, since information regarding the effects of pre-mating exposure on reproductive functions and fertility in parental animals is insufficient, we determined that classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 3-month oral administration test using rats, no signs of toxic effects were reported other than decreased acetic acid and maleic acid dehydrogenase activities at 100 mg/kg/day, which is the upper limit of Category 2 guidance values (BUA Report No. 126 (1993)). In addition, in a 31-day oral administration test using rats, no toxic effects were noted other than delayed body weight gain at 375, 750, and 1500 mg/kg bw/day (90-day conversion: 125, 250, and 500 mg/kg bw/day, respectively), which are above Category 2 guidance values (BUA Report No. 126 (1993)). These results indicate that the substance falls under the "Not classified" category (oral route); however, due to lack of information on other administration routes, the substance was classified into the "Classification not possible" category. As additional notes, in a 13-week oral administration test using rats, effects of administration on the liver and blood are reported (RTECS (2006)); however, the test dose and duration were 9100 mg/kg/13 weeks, and this study is documented in the List 3 data source. As such, we did not use this study for evaluation.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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