GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：sulphanilic acid; 4-aminobenzenesulphonic acid
CAS：121-57-3
Result：
| ID: | 20A2184 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solid | Classification not possible | - | - | - | - | No data available. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | It contains chemical groups associated with self-reactive properties; information on self-reactive properties is not available. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Its autoignition point is > 400degC (IUCLID (2000)), which is above 70degC. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Organic compounds containing oxygen, which is chemically bonded to elements other than hydrogen and carbon; information on its oxidizing properties is not available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Since its rat LD50 values are reported to be 12300 mg/kg and 13200 mg/kg using technical grade test substance (IUCLID (2000)), the substance was classified into "Not classified". |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Skin irritation tests using rabbits that received 24-hour exposure found the substance slightly irritating (IUCLID (2000)). In other studies, 20-hour exposure resulted in development of mild and slight rubor (IUCLID (2000)). Based on these results, the substance was classified into "Not classified" using the JIS classification criteria (Category 3 in the United Nations classification). |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Eye irritation tests using rabbits found the substance moderately irritating 24 hour after application (IUCLID (2000)). It is rated as Xi: R36 in the EU classification (EU-Annex 1 (accessed in November 2008)). Based on this information, the substance was classified into Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Two different guinea pig maximization tests found the substance sensitizing (IUCLID (2000)). In addition, several skin sensitizing tests using guinea pigs yielded positive results (IUCLID (2000)). Furthermore, it is rated as R43 in the EU classification (EU-Annex 1 (accessed in November 2008)). Thus, the substance was classified into Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification is not possible due to lack of in vivo mutagenicity test data. As additional background information, Ames tests (in vitro mutagenicity tests) gave negative results (NTP DB (accessed in November 2008), IUCLID(2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Since its 48-hour EC50 = 85.66 mg/L for crustaceans (Daphnia magna) (IUCLID, 2000), the substance was classified into Category 3. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Its classification for acute toxicity is Category 3 and it is not rapidly degradable (non-biodegradable, BOD degradability: 3% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2001)), the substance was classified into Category 3. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |