GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：sodium 3-nitrobenzenesulphonate
CAS：127-68-4
Result：
| ID: | 20A2193 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | The molecule contains chemical groups (nitro compounds) associated with explosive properties. Its oxygen balance is -60.4, which is higher than -200. Since no additional information is available, classification is not possible. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solid | Classification not possible | - | - | - | - | Since no appropriate test results are available, classification is not possible. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | It contains chemical groups associated with explosive properties; no data on self-reactive properties are available. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Its autoignition point is 380degC (IUCLID (2000)), which is above 70degC. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140degC) substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Its water solubility is 200g/L (IUCLID (2000)) and the substance presumably does not release flammable gases in contact with water. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | It contains oxygen, which is chemically bonded to elements other than hydrogen or carbon; no information on its oxidizing properties is available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on its rat LD50 of > 5000 mg/kg (IUCLID (2000)), the substance was classified into the "Not classified" category. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not classified | - | - | - | - | Its rat LC50 is > 5.1 mg/L/4h (IUCLID (2000)), which is above its saturated vapour pressure concentration. Thus, we determined that the test was conducted in a dust state and classified the substance into the "Not classified" category using the JIS classification criteria (Category 5 or "Not classified" category in GHS classification). |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | - | Skin irritation tests using rabbits (Draize tests) found the substance not irritating. Based on this description, it was classified into the "Not classified" category. |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Since skin irritation tests using rabbits (Draize tests) found the substance irritating (IUCLID (2000)), and it is rated as X; R36 in the EU classification (EU-Annex 1 (accessed in November 2008)), the substance was classified into Category 2. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Guinea pig maximization tests (Directive 84/449/EEC B6) found the substance sensitizing (IUCLID (2000)). In addition, it is rated as R43 in the EU classification (EU-Annex 1 (accessed in November 2008)). Thus, the substance was classified into Category 1. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Since micronucleus assays using mice (OECD TG474) (in vivo mutagenicity tests using somatic cells) gave negative results (IUCLID (2000)), the substance was classified into the "Not classified" category. In addition, several in vitro mutagenicity tests also yielded negative results. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Rat or rabbit tests found the substance not reproductively toxic (IUCLID (2000)). However, since detailed testing methods are not provided, classification is not possible. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In a 28-day repeated oral administration test using rats, transient salivation was noted at 1000 mg/kg/day, and the symptom was determined to be caused by irritating property of this substance. No changes were detected in terms of hematological examination items as well as histopathological changes indicative of hematopoietic disorder although decreased hemoglobin concentrations were noted for females in 1000 mg/kg/day groups and lowered hematocrit values were detected for males in all dose groups (100-1000 mg/kg). In addition, no differences were detected between treated and control groups in clinical observations, pathological examinations, and blood biochemistry examinations; and NOEL is reported to be 300 mg/kg (90-day conversion: 100 mg/kg/day) for both sexes (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), accessed in November 2008). In a 4-week repeated oral administration test using rats, no abnormalities were observed in histopathological and clinical examinations other than occult blood reaction detected in urine in the highest dose groups; and NOAEL was 1405 mg/kg/day (90-day conversion: 468 mg/kg/day) (IUCLID (2000)). Overall, since NOEL and NOAEL obtained in these two oral administration tests are above Category 2 guidance values, the substance falls under the "Not classified" category (oral route). However, because no test results via other administration routes are available, the substance was classified into the "Classification not possible" category. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Since its 48-hour LC50 = 8665 mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into the "Not classified" category. |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since it is water soluble (water solubility = 2.77E+005 mg/L (PHYSPROP Database, 2008)), and its classification for acute toxicity is the "Not classified" category, the substance was classified into "Not classified". |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |