GHS Classification Result

Chemical Name：zinc bis(dibutyldithiocarbamate)
CAS：136-23-2

Result：
ID: 20A2197
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Its melting point is 100-138degC (Sax 11th, 2004; Lide 88th, 2008; IUCLID, 2000). Test methods applicable to solid substance having their melting point <= 140degC are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Its water solubility is 0.0104 mg/L at 25degC (SRC, accessed in November 2008) and it is stable in contact with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on its rat LD50 being => 5000 mg/kg bw (OECD TG 401, GLP) (IUCLID, 2000), the substance was classified into the "Not classified" category.
1 Acute toxicity （Dermal） Not classified - - - - Based on its rabbit LD50 being >= 2000 mg/kg bw (OECD TG 402, GLP) (IUCLID, 2000), the substance was classified into the "Not classified" category (Category 5 or the "Not classified" category in the United Nations classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - 20 humans showed no positive responses to the substance in 48-hour human patch tests (IUCLID, 2000). In rabbit tests, skin irritation was represented by a Draize score of 0.1, and the irritation had ceased 3 days after administration (HSDB, 2006). Other rabbit tests found the substance not irritating (IUCLID, 2000). Based on these results, the substance was classified into the "Not classified" category. As additional background information, it is rated as R36/37/38, an irritant, in the EU classification (EU-Annex 1, accessed in November 2008).
3 Serious eye damage/eye irritation Not classified - - - - Rabbit tests that are in accordance with FDA guidelines found the substance slightly irritating (IUCLID, 2000), and rabbit Draize tests found the substance not irritating (score 0.3 out of 110) (IUCLID, 2000). Based on these results, the substance was classified into the "Not classified" category. As additional background information, it is rated as R36/37/38, an irritant, in the EU classification (EU-Annex 1, accessed in November 2008), which is equivalent to Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Patch testing on 20 human volunteers produced no positive reactions on initial application, no positive reactions during the course of 15 serial applications, and no positive reactions on a subsequent rechallenge (HSDB, 2006). Although these negative results indicate that the substance falls under the "Not classified" category, it is rated as R43 in the EU classification (EU-Annex 1, accessed in November 2008), which is equivalent to Category 1. Due to contradicting information, the substance was classified into the "Classification not possible" category.
5 Germ cell mutagenicity Classification not possible - - - - The substance was classified into the "Classification not possible" category due to lack of in vivo test results. As additional background information, in vitro mutagenicity tests (Ames tests (IUCLID, 2000; HSDB, 2006) and mouse lymphoma tests (HSDB, 2006)) yielded negative results.
6 Carcinogenicity Classification not possible - - - - An 18-month study using mice (oral intubation for 21 days and mixed diet administration for 79 weeks, or single subcutaneous injection and mixed diet administration for 79 weeks) found no adverse effects of the test substance, and no statistically significant increase in tumor incidences were observed in this study (IUCLID, 2000). This report indicates that the substance falls under the "Not classified" category. However, since not sufficient data are available for evaluation of the substance, it was classified into the "Classification not possible" category.
7 Reproductive toxicity Classification not possible - - - - In the test in which pregnant mice were treated with the test substance via subcutaneous injections, no embryotoxic or teratogenic effects were observed (HSDB, 2006). These results indicate that the substance fall under the "Not classified" category. However, since there is no information on fertility of parental animals, the substance was classified into the "Classification not possible" category.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - It is rated as R37 in the EU classification (EU-Annex 1, accessed in November 2008), which is equivalent to Category 3 (respiratory irritation). However, due to lack of relevant test results, the substance was classified into "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 17-week repeated oral administration test using rats, no effects of the substance were found in hematological, blood biochemical, or urine examinations; only increased kidney or liver weights were noted at 2500 ppm (conversion value: 125 mg/kg bw/day) (IUCLID, 2000). Since the administration doses fell under the "Not classified" category guidance values, the substance is considered to be categorized into "Not classified". However, because the test focused only on one administration route (oral) and one animal species (rat), due to insufficient information available, the substance was classified into the "Classification not possible" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 48-hour EC50 = 0.74 mg/L for crustaceans (Daphnia magna) (IUCLID 2000), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 1, and it is not rapidly degradable (estimated value: SRC: BioWin V4.10), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information