GHS Classification Result

Chemical Name：dodecyl methacrylate
CAS：142-90-5

Result：
ID: 20A2201
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Since its flash point is 126degC in a closed system (HSDB, 2004; IUCLID, 2000), which is => 93degC, the substance was classified into "Not classified".
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - The substance contains an unsaturated bond (methacrylic group). Due to lack of data, classification is not possible.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 296degC (HSDB, 2004; IUCLID, 2000). Because its flash point is => 70degC, the substance was classified into "Not classified" based on the classification guidelines.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on its rat LD50 being => 5000mg/kg bw (HSDB, 2004), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on its rabbit LD50 value => 3000mg/kg bw (HSDB, 2004), the substance was classified into "Not classified" (Category 5 or the "Not classified" category in the UN classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In Draize tests using rabbits, the substance was found to be slightly irritating 24 hours after application (IUCLID, 2000), and it is categorized into R36/37/38 in the EU classification, which indicates that it is irritating (EU-Annex 1, November 2008). Based on this information, the substance was classified into "Not classified" (Category 3 in the UN classification).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In Draize tests using rabbits,slight irritation was observed (IUCLID, 2000), and it is categorized into R36/37/38 (EU-Annex 1, November 2008). Based on this information, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - In sensitization tests using guinea pigs, this substance showed the highest sensitization potential (HSDB, 2004) among 11 substances tested (derivatives with the length of alkyl side chain between C1 and C18 (Kanazawa, Y. et al. Contact Dermatitis 40 (1): 19-23 (1999)). Although this result indicates that the substance is sensitizing, the testing method was not described and the proportion of animals that experienced sensitization was unclear. Thus, the substance was classified into "Classification not possible".
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In intravenous injection tests using dogs, only the description that an abrupt fall in blood pressure was observed was provided (HSDB, 2004). There are no other data available which can be used as a basis for classification. Thus, the substance was classified into "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a test using mice, strong sweating and excitation, as well as incidences of sedation and body weight decrease at high doses were observed (HSDB, 2004). However, because the administration method, administration doses, and administration duration were unclear in this test, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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