GHS Classification Result

Chemical Name：di-n-butyl ether; dibutyl ether
CAS：142-96-1

Result：
ID: 20A2202
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point is 37degC (closed cap) (Merck (14th, 2006)), which falls between 23 and 60degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 175degC (Ullmanns (E) (2003)), which exceeds 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Since its rat LD50 = 7.40ml/kg (equivalent to 5,686mg/kg based on its density of 0.7684) (PATTY (5th, 2001)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Since its rabbit LD50 = 10.08ml/kg (equivalent to 7,745mg/kg based on its density of 0.7684) (PATTY (5th, 2001)), the substance was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - In an inhalation test using rats, two out of six treated rats died at 4,000ppm (PATTY (5th, 2001)). However, due to insufficient information being available on this test, classification is not possible. This classification was conducted using a cutoff value for the gas because its saturated vapour pressure concentration is 1,6447ppmV and the concentration used in the test (4,000ppm) was lower than 90% of the saturated vapour pressure concentration.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In a test using rabbits, the substance scored 4 for irritation (PATTY (5th, 2001)), and in a different test, severe irritation but no necrosis was detected (HSDB (2008)). In addition, the substance has been categorized into Xi R38 in the EU classification (EU-Annex 1 (2008)). Based on this information, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since rabbit tests resulted in the substance scoring 1 for irritation caused by corneal damage (PATTY (5th, 2001)), and it has been categorized into Xi R36 in the EU classification, it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo data. In Ames tests, results were negative. (NTP DB (accessed in November 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, liver), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system, liver)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In oral administration tests using mice, a fatty liver was detected at the doses of 576mg/kg and 457mg/kg that fall within the range of Category 2 guidance values (RTECS (2007)). In addition, in inhalation exposure tests using rats, a 4-hour exposure to 20.2mg/L, which exceeds the range of Category 2 guidance values, resulted in effects on the liver and respiratory tracts, and a fatty liver (RTECS (2007)). Furthermore, in mice, an exposure to 10mg/L for 30 minutes (4-hour conversion: 1.25mg/L) resulted in motor ataxia and effects on the lung and respiratory tracts (RTECS (2007)); an exposure to 10mg/L for 75 minutes (4-hour conversion: 3.13mg/L) resulted in narcotic effects, effects on the lung and respiratory tracts, and a fatty liver (RTECS (2007)); and an exposure to 169mg/L for 15 minutes resulted in narcotic effects. Although these data originate from the List 3 literature source, common symptoms were observed in several tests. Therefore, the substance was classified into Category 1 for the respiratory system and liver, and Category 3 for narcotic effects. In addition, an exposure to 200ppm for 15 minutes has been documented to cause irritation to the eyes and nose in humans (HSDB (2008)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 4-week (5 days a week) forced oral administration test using rats, mild histological changes were detected in the thyroid gland, but no changes were observed with the level of circulating thyroxin (T4) or triiodothyronine (T3) (HSDB (2008)). In addition, no effects were detected except for elevation in the activities of xenobiotic metabolizing enzymes at 200mg/kg (90-day conversion: 47.6mg/kg) that falls within the Category 2 guidance values (HSDB (2008)). Also, in two other 4-week oral administration tests using rats, noticeable effects were not observed except for activation and elevation of xenobiotics-metabolizing enzymes at both 400mg/kg (90-day conversion: 133mg/kg) and 4,000mg/kg (90-day conversion: 1,333mg/kg) that exceed the range of Category 2 guidance values (RTECS (2007)). Although these results indicate the classification of the substance into the "Not classified" category (oral route), information on other routes is not available. Thus, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 48-hour LC50 = 26mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 3 and it is not rapidly degradable (non-biodegradable, BOD degradability: 3% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1986)), the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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