GHS Classification Result

Chemical Name：molybdenum trioxide
CAS：1313-27-5

Result：
ID: 20A2216
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Since the substance is the final oxidation product of a molybdenum compound (Ullmann's (E) (6th, 2003)), it is nonflammable. Thus, it was classified into "Not classified".
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since the substance is the final oxidation product of a molybdenum compound (Ullmann's (E) (6th, 2003)), it is nonflammable. Thus, it was classified into "Not classified".
11 Self-heating substances and mixtures Not classified - - - - Since the substance is the final oxidation product of a molybdenum compound (Ullmann's (E) (6th, 2003)), it is nonflammable. Thus, it was classified into "Not classified".
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Its water solubility is 0.49 g/L (28degC) (Ullmann's (2006)); it is stable in water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Its rat LD50 values are 125 mg/kg (DFGOT (2008)) and 83 mg Mo/kg (HSDB (2005)), which are equivalent to Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - Since no data are available, classification is not possible. The EU has rated the substance as +R36/37: Irritating to eyes and respiratory system (EU-Annex 1 (accessed in December 2008)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Since no in vivo data available, classification is not possible. As relevant information, in vitro mutagenicity tests (Ames tests and chromosomal aberration tests) have yielded negative results (NTP TR 462 (1997)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In 2-year inhalation tests using rats or mice (rats: 106 weeks, mice: 105 weeks), the development of tumors did not appear to increase in either sex of rats. However, adenoma or carcinoma in the lung were observed in the following breakdown: in male mice that were divided into groups of 50, 27, 21 and 18 animals developed these symptoms at 10 mg/m3, 30 mg/m3, and 100 mg/m3 exposure, respectively; in female rats, 6, 8 and 15 animals developed these symptoms at 10 mg/m3, 30 mg/m3, and 100 mg/m3 exposure, respectively (NTP TR 462 (1997)). In comparison with control groups, the difference in development of the symptoms among exposure doses rarely noticeable in male, incidences increased proportionally with exposure doses in female (NTP TR 462 (1997). Thus, the substance was classified into Category 2. As relevant notes, the substance has been rated as Category 3 by the EU and 3B in the DFG evaluation (DFGOT vol. 18 (2000)).
7 Reproductive toxicity Classification not possible - - - - In inhalation tests using mice, comparison was made between treated and control groups in terms of weights of testis and forms and motility of spermatozoa: no signs of toxic effects were detected and there were no effects on fertility of the male (DFGOT, 2008). However, since these results alone do not provide sufficient data, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 1 (heart, kidney, liver) Danger H370: Causes damage to organs (heart, kidney, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In 2-hour inhalation tests using rats, dystrophic changes in the heart, kidneys and liver occurred at 64 mg/m3 (4-hour conversion value: 32 mg/m3 or 0.032 mg/L) (DFGOT vol.18 (2000)). Based on this document, the substance was classified into Category 1 (heart, kidney, liver).
9 Specific target organ toxicity - Repeated exposure Category 1 (lung), Category 2 (liver, kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (lung)
H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 2-month inhalation tests using rats, dystrophy of the kidney and liver, focal fatty degeneration in the liver, thickening of the alveolar walls, interstitial pneumonia, and emphysema were observed at the doses of 3-10 mg/m3 (90-day conversion values: 0.0018-0.007 mg/L) (DFGOT vol.18 (2000)); and fibrotic changes were detected in the lungs at the dose of 50 mg/m3 (0.05 mg/L) in 4-8 month intratracheal administraion tests. In addition, in 1-month tests using guinea pigs that received forced oral administration, changes in the liver (fatty degeneration) and kidney (focal necrosis and granulomatosis) were observed at the doses of 25-200 mg/animal (90-day conversion values: 10 mg/kg bw-90 mg/kg bw). And in 5-week inhalation tests, vacuolation and necrosis in the liver were detected at the dose of 205 mg/m3 (90-day conversion value: 0.02 mg/L) (DFGOT vol.18 (2000)). Moreover, in the humans cases, 3 of 19 persons, who were exposed to 1-25 mg/m3 of molybdenum (VI) trioxide for 4 to 7 years, experienced respiratory difficulties and frequent coughing, and they were diagnosed as pneumoconiosis using X-ray (DFGOT vol.18 (2000)). Based on these documents, the substance was classified into Category 1 (lung) and Category 2 (liver, kidney).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 96-hour LC50 = 70 mg/L for fish (fathead minnow) (Aquire 2008), the substance was classified into Category 3.
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 3, and it is not considered rapidly degradable as it is a metal compound, the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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