GHS Classification Result

Chemical Name：chloridazon (ISO); 5-amino-4-chloro-2-phenylpyridazine-3-(2H)-one; pyrazon
CAS：1698-60-8

Result：
ID: 20A2222
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and oxygen (but not fluorine), which are chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Its rat LD50 values are 647, 1210, 1000-1470, 1459, 3000, 3030, 3400, 3600, 4200 mg/kg bw (IUCLID (2000)); these values include 4 cases of Category 4 and 5 cases of "Not classified" category. From these results, the substance was classified into "Not classified" using the JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity （Dermal） Not classified - - - - Based on its rat LD50 values of > 2500 and > 5000 mg/kg, and its rabbit LD50 value of > 4000 mg/kg (IUCLID (2000)), the substance was classified into "Not classified" (Category 5 or "Not classified" in the United Nations classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Its rat LC50 values are > 0.15 mg/L/4h and > 0.25 mg/L/4h (IUCLID (2000)), which are less than its saturated vapour pressure concentration of 0.598 mg/L. The concentration of 0.25 mg/L is a concentration of pesticide formulations and is equivalent to 0.16 mg/L of this substance. Overall, based on these LC50 values of > 0.15 mg/L (conversion value: 17 ppm) and > 0.16 mg/L (conversion value: 18 ppm), the category for this substance cannot be determined; thus, it was classified into "Classification not possible".
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Since its rat LC50 value of > 30.8 mg/L/4h (IUCLID (2000)) is higher than its saturated vapour pressure concentration of 0.598 mg/L, the substance was in a mist state. From these results, the substance was classified into "Not classified".
2 Skin corrosion/irritation Classification not possible - - - - Using rabbits, the substance has been evaluated to be not irritating in three tests, and slightly irritating in four tests (IUCLID (2000)). No other detailed information was obtained, and the substance was classified into "Classification not possible" due to lack of data.
3 Serious eye damage/eye irritation Not classified - - - - Using rabbits, the substance has been evaluated to be not irritating in four studies, and slightly irritating in one study (IUCLID (2000)). In two tests in which no irritation was detected in rabbits, it is documented that redness was observed 1 and 24 hours after the application and the symptom healed in 8 days; or slight corneal hyperemia was observed 6 days after the application and it healed in 4 to 5 days. Since the symptoms were mild and the substance was evaluated to be not irritating, it was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In guinea pigs (maximization tests: OECD 406, GLP-compliant), the substance was evaluated to be not sensitizing (IUCLID (2000)). In humans, allergic reactions were not detected in patch tests (IUCLID (2000)). Based on these results, the substance was classified into "Not classified". According to the EU, the substance was rated as R43 (equivalent to Category 1) (EU-Annex 1 (accessed in December 2008)).
5 Germ cell mutagenicity Not classified - - - - Since in vivo tests using mice (dominant lethal tests and micronucleus tests) yielded negative results (IUCLID (2000)), the substance was classified into "Not classified". Among in vitro tests, Ames tests and unscheduled DNA synthesis tests yielded negative results.
6 Carcinogenicity Not classified - - - - Signs of carcinogenicity were not detected in the following tests documented: 103-109-week oral administration tests using rats (SD) that were applied with 150 to 4050 ppm, 81-96-week oral administration tests using mice (CFLP) that were applied with 160 to 20000 ppm (IUCLID (2000)), mixed diet tests using mice (B6C3F1/CrlBr) that were applied with 0 to 5000 ppm, and mixed diet tests using rats that were applied with 0 to 1000 ppm (IUCLID (2000)). Based on these results, the substance was classified into "Not classified".
7 Reproductive toxicity Not classified - - - - In 3-generation tests using rats that received 150 to 1350 ppm, symptoms of reproductive toxicity (mating, pregnancy rate, gestational period, and litter parameters) or teratogenicity were not detected (IUCLID (2000)). In teratogenicity tests using rats that received 0 to 250 mg/kg bw (OECD 414, GLP-compliant) and rabbits that received 55 to 495 mg/kg bw (OECD 414, GLP-compliant), no signs of teratogenicity, embryotoxicity, or fetal toxicity were observed at doses that showed toxic effects on maternal animals (IUCLID (2000)). In other tests, either reproductive toxicity or developmental toxicity was detected in mice that received 5000-10000 ppm (FDA guidelines) or rats that received 0 to 1600 ppm (HSDB (2007)). Based on these negative results, the substance was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - When pyrason was given intragastrically to rats, mice, cats, and guinea pigs, increased reflex excitability, disordered movement coordination, tonic convulsions, hypotension and decreased body temperatures were observed in the animal groups that received the doses of 2 to 4 ml (values corrected for specific gravity: 3.08-6.16 mg (PM (14th, 2006)) (IUCLID (2000)). However, administration doses of the solid substance were documented in terms of volume, doses per body weight could not be calculated, and only one dataset of a forced oral administration test was available. Thus, the substance was classified into "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 35-day mixed diet tests using rats that received doses of 300-19200 ppm (90-day conversion values: 9.7-622 mg/kg bw), the effects of the substance observed across all the dose groups tested were limited to an increase in absolute and relative liver weight, and the effects on clinicochemical parameters (such as reduced glucose and increased bilirubin) (IUCLID (2000)). In addition, in 3-month mixed diet tests using dogs that received doses of 100 to 10000 ppm (2.4-326.6 mg/kg), findings were limited in changes in organ weight and clinicochemical parameters observed at 326.6 mg/kg (IUCLID (2000)); however, these results indicate that the substance is to be categorized into "Not classified" (oral route). Since information on other administration routes is not available, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 72-hour EC50 = 0.6 mg/L for algae (Pseudokirchneriella subcapitata) (IUCLID, 2000), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin v4.10), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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