GHS Classification Result

Chemical Name：pentaerythritol triacrylate
CAS：3524-68-3

Result：
ID: 20A2230
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - The substance contains an acrylic group; classification is not possible due to lack of data.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - The substance does not contain fluorine or chlorine, or if it contains these elements, it is an organic substance with these elements bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Its rat LD50 values are documented to be 1350 mg/kg and 2.46 ml/kg (=2902 mg/kg bw) (NTP GMM. No. 4 (2005)). Of these values, 1350 mg/kg was used as grounds for classifying the substance into Category 4. Also, there is another dataset indicating that its rat LD50 is between 500 and 5000 mg/kg bw (NTP GMM. No. 4 (2005)).
1 Acute toxicity （Dermal） Not classified - - - - Its rabbit LD50 values are 4 ml/kg (= 4720 mg/kg) (NTP GMM. No. 4 (2005)) and > 2000 mg/kg (NTP GMM. No. 4 (2005)). These values fall under "Not classified" category using the JIS classification criteria (Category 5 or "Not classified" in the United Nations classification). Also, there is another dataset indicating that its rabbit LD50 is between 200 and 2000 mg/kg (NTP GMM. No. 4 (2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		In Draize tests using rabbits, the substance was found to cause moderate irritation (RTECS, 2003). In addition, it is rated as GR38 in the EU classification. Thus, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		In rabbit tests, the substance was reported to cause severe and corrosive irritation as well as corneal opacity (NTP GMM. No. 4 (2005)); another study also documented that it causes severe irritation (NTP GMM. No. 4 (2005)). Based on these reports, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In several tests using guinea pigs, including maximization tests and Draize tests, the substance was found to be sensitizing (NTP GMM. No. 4 (2005)). In addition, positive reactions were detected in sensitization tests applied to volunteer people (NTP GMM. No. 4 (2005)). Also, there are several reports in which patch tests provoked positive reactions in workers who handled this substance (NTP GMM. No. 4 (2005)). Based on these reports, the substance was classified into Category 1. It is rated as R43 in the EU classification (EU-Annex 1 (accessed in December 2008)).
5 Germ cell mutagenicity Classification not possible - - - - In 13-week micronucleus tests using peripheral blood of mice that underwent dermal administration (in vivo mutagenicity tests using somatic cells), negative results were obtained in both sexes of B6C3F1 mice (NTP DB (accessed in December 2008)). On the other hand, in TgAC (FVB/N) hemizygous mice, positive results were yielded in females, while a decision between positive and negative could not be made in males (NTP DB (accessed in December 2008)). Since both tests were not conducted using a conventional test system, these results could not be used for classification purposes. Thus, the substance was classified into "Classification not possible". Also, Ames tests (in vitro mutagenicity tests) yielded negative results (NTP DB (accessed in December 2008)).
6 Carcinogenicity Classification not possible - - - - In dermal administration tests, mice were topically applied with 3 mg of acetone solution, containing 15 % concentration of erythritol acrylic acid (25% pentaerythritol triacrylate, 65% tetraacrylate, and 10% diacrylate), 3 times a week: no skin tumors were detected (NTP GMM. No. 4 (2005)). In other dermal administration tests using mice that were applied with pentaerythritol acrylic acid esters, an increased incidence of hepatoma occurred; however, a conclusion could not be drawn, according to the document (NTP GMM. No. 4 (2005)). In yet other dermal administration tests, mice were topically applied with 2.5 mg of a white mineral oil solution, which contained 5% concentration of pentaerythritol triacrylate, for 80 days: while no skin tumors were detected, squamous cell carcinoma of the skin, lymphomas with spleen or lymph node involvelment were documented. The EPA views these cases as limited evidence of carcinogenicity (NTP GMM. No. 4 (2005)). In any case, all tests provided limited evidence of carcinogenicity and no data on other animal species but mice are available. Thus, the substance was classified into "Classification not possible".
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In developmental toxicity tests using rats that underwent dermal administration, while mild maternal toxicity was observed, fetal teratogenicity was not detected (NTP GMM. No. 4 (2005)). On the other hand, in developmental toxicity tests using rats that underwent oral administration during the organogenetic period, rates of postplantation loss and fetal mortality were affected by the administration (RTECS (2003); National Technical Information Service (NTIS)); thus, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In 8-hour inhalation exposure tests using rats, no mortality was documented (NTP GMM. No. 4 (2005)); however, information such as exposure concentrations and symptoms observed was not available. Thus, the substance was classified into "Classification not possible" due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 14-week dermal administration tests using rats (doses: 0.75, 1.5, 3, 6, and 12 mg/kg), changes in hematological values were detected; however, these changes were considered to be secondary effects related to dermal disorder (NTP GMM. No. 4 (2005)). In addition, 17-day dermal exposure and 13-week dermal administration tests have been conducted (NTP GMM. No. 4 (2005)), in which, as far as toxic effects of the substance was concerned, the only descriptions found were regarding necrosis and hyperplasia on the skin where the substance was applied, and parakeratosis; its effects on organs were not available. As such, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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