GHS Classification Result

Chemical Name：aluminium chloride, anhydrous
CAS：7446-70-0

Result：
ID: 20A2239
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - The substance is a non-flammable solid (ATSDR (2008); Hommel (1996); ICSC (2005)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - The substance is non-flammable (ATSDR (2008); Hommel (1996); ICSC (2005)).
11 Self-heating substances and mixtures Not classified - - - - The substance is non-flammable (ATSDR (2008); Hommel (1996); ICSC (2005)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Its water solubility is 45.1 g/100 g H2O at 25degC (Lide (88th, 2008)) and it is stable in contact with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Its rat LD50 values are 370 mg/kg bw (ATSDR (2008)), 1100 mg/kg bw (JECFA (series 24: 2007)), and 3700 mg/kg bw (JECFA (series 24: 2007)). Since the majority of these values fall under Category 4 guidance values, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the following information, the substance was classified into Category 1: open irritation tests using rabbits found that the substance causes severe irritation (RTECS (2008)); open irritation tests using mice found that the substance causes severe irritation (RTECS (2008)); and human tests found that the substance is corrosive (IUCLID (2000)) and causes moderate irritation (IUCLID (2000)). In addition, mild irritation was observed in humans to whom the test substance was applied for 3 days or more (HSDB (2005)). It is also reported that the use of medicine containing aluminum chloride for the treatment of hyperhidrosis worsened miliaria (HSDB (2005)). The substance is rated as C; R34 in the EU classification.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		The substance was classified into Category 1 for the following reasons: human tests found that the substance is highly corrosive (IUCLID (2000)); there are human cases of corneal burns involving the substance (HSDB (2005)); and it was previously classified into Category 1 for skin irritation / corrosion (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - The substance was classified into "Not classified" based on the following information: Buehler tests using guinea pigs found that the substance is not sensitizing (IUCLID (2000)); maximization tests using guinea pigs found that the substance is not sensitizing (IUCLID (2000)); maximization tests on humans found that the substance is not sensitizing (IUCLID (2000)); patch tests on humans found that the substance is not sensitizing (IUCLID (2000)). On the other hand, positive reactions were found in patch tests applied to patients whose itchy dermatitis worsened by using antiperspirant containing aluminum chloride (EHC No. 194 (1997)), and in patch tests applied to children who received a shot of aluminum-bound vaccine during infancy to prevent hypersensitivity (EHC No. 194 (1997)); however, the link between the positive reaction and aluminum chloride is not clear.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified into Category 2 based on the positive results obtained in micronucleus tests using bone marrow cells of mice that underwent intraperitoneal administration (in vivo mutagenicity tests using somatic cells) (ATSDR (2008). In in vitro tests, positive results were obtained in chromosomal aberration tests and micronucleus tests using human peripheral lymphocytes (ATSDR (2008)) while negative results were obtained in Ames tests and mouse lymphoma assays (ATSDR (2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is documented that no effects of the substance were detected in either 3-generation tests using rats that underwent oral administration through drinking water (19.3 mg/kg/day) (JECFA (series 24: 2007)), or developmental toxicity tests using rats that were fed with a mixed diet (91 mg/kg/day) between day 6 and 19 of the gestational period (IUCLID (2000)). However, in forced oral administration tests using mice that were applied with 41 mg Al/kg/day (202 mg AlCl3/kg/day) between day 7 and 16 of the gestational period, an increased embryo resorption was observed, while toxic effects on the parents were unclear (ATSDR (2008)). In addition, in mixed diet tests using rats that were fed with 272 mg Al/kg/day (1343 mg AlCl3/kg/day) between day 1 and 20 of the gestational period, significant impairment in the righting reflex and grasping reflex were observed in rat pups, while toxic effects on the parents were unclear (ATSDR (2008)). Moreover, in forced administration tests using rats that were applied with 900 or 1800 mg/kg on day 15 of the gestational period, significant effects were detected on timing of pinna detachment and eye opening, and learning acquisition in offspring, while toxic effects on the parents were unclear. Since exposure to the test substance during prenatal period is documented to affect development and behavior of the offspring (IUCLID (2000)), the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although dermal toxicity tests using rabbits or mice have been documented (RTECS (2008), no descriptions of specific toxic symptoms are available other than those on irritation and inflammation in the treated area. Thus, classification is not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 60-day forced oral administration tests using rats, an increased acetylcholinestrase activity was observed in olfactory bulb, striatum and hypothalamus at the dose of 320 mg Al/kg bw (90-day conversion value: 213 mg/kg/day), which falls under the guidance values for the "Not classified" category (CaPSAR (2000)), indicating the effects of the substance on the nervous system. In 180-day tests using rats that underwent administration in drinking water, reduced spontaneous locomotor activity, impaired acquisition, extinction and reacquisition of an active avoidance task were observed at the dose of 12 mg Al/day per rat (59 mg AlCl3/day per rat), which falls under the guidance values for Category 2 (CaPSAR (2000). Furthermore, in 3-month tests using rats that underwent administration in drinking water, impairment of post-rotatory nystagmus was observed at the dose of 43.1 mg/kg/day, which falls under the Category 2 guidance values (ATSDR (2008)). Based on these results, the substance was classified into Category 2 (nervous system). Also, in 21-day forced oral administration tests using rats, a significant decrease in red blood cells, hematocrit, and serum iron concentration; an increase in platelets; and a decrease in hemoglobin were found, suggesting that exposure to aluminum may cause normocytic anemia (IUCLID (2000)). However, the exposure dose was 494 mg/kg/day (90-day conversion value: 115 mg/kg/day), which fell under the guidance values for the "Not classified" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 96h LC50 = 0.37 mg/L for fish (Atlantic salmon) (EHC 194 1997), the substance was classified into Category 1.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 1, it is an inorganic matter, and it is not rapidly degradable, the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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