GHS Classification Result

Chemical Name：trisodium hexafluoroaluminate; cryolite
CAS：13775-53-6

Result：
ID: 20A2257
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Non Flammable (IUCLID (2000))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non Flammable (IUCLID (2000))
11 Self-heating substances and mixtures Not classified - - - - Non Flammable (IUCLID (2000))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Its water solubility is 0.41 g/L at 25degC (IUCLID (2000)), and it is stable in contact with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - An inorganic substance containing fluorine (but not oxygen); Test data are not available.
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on rat LD50 values of this substance (CAS No. 13775-53-6: synthetic mineral): > 2000 mg/kg bw (GLP-compliant), > 2500 mg/kg bw and > 5000 mg/kg bw (IUCLID (2000)), the substance was classified into "Not classified". The CAS No. for the naturally-occurring mineral, Cryolite, is 15096-52-3.
1 Acute toxicity （Dermal） Not classified - - - - Based on its rat LD50 value of > 2000 mg/kg (GLP-compliant, IUCLID (2000)), the substance was classified into "Not classified" (Category 5 or "Not classified" category in the United Nations classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In the 8 or 24-hour exposure tests using rabbits (IUCLID (2000)), the substance was classified into "Not classified" since no signs of irritation were detected.
3 Serious eye damage/eye irritation Not classified - - - - In the tests using rabbits that received this substance, no signs of irritation were detected (IUCLID (2000)); thus, the substance was classified into "Not classified". With regard to cryolite, the following have been documented: irritation to workers' eyes (Patty (5th, 2001)), eye damage (HSFS (2000)), severe eye irritation in contact with the substance, burns and possible loss of eyesight (Sittig (5th, 2008)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - This substance (synthetic mineral) was classified into "Classification not possible" due to lack of data. With regard to Cryolite (naturally-occurring mineral), rash, eruption, and eczema were detected in workers (Patty (5th, 2001)).
5 Germ cell mutagenicity Classification not possible - - - - In in vivo tests using bone marrow cells of rats that were treated with this substance (synthetic mineral), an increase in chromosomal aberration was observed in animal groups that were applied with 3 mg/m3 (IUCLID (2000)). However, the substance was classified into "Classification not possible" due to lack of detailed data. Regarding in vitro tests (Ames tests) on this substance (IUCLID (2000)), results were negative.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - There are no test data available on this substance (synthetic mineral). In forced oral administration tests using mice that were treated with 0 to 300 mg/kg/day of cryolite (naturally-occurring mineral) between day 6 and 15 of the gestational period, skeletal abnormalities (bent rib or scapula) were detected. However, descriptions on reproductive toxicity in parental animals are not available (HSDB (2000)) and other animal test data are also unavailable, making categorization of the substance difficult. Thus, the substance was classified into "Classification not possible" due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are no test data available on this substance (synthetic mineral). With regard to Cryolite (natural mineral), the following have been observed: irritation in the mouth or pharynx in humans (Patty (5th, 2001)), cases of nausea and vomiting in workers (HSDB (2005)), coughing caused by irritation of the nose, throat or lungs through inhalation (HSFS (2000)), possible pulmonary edema induced by respiratory tract irritation or high dose exposure (Sittig (5th, 2008)). Based on these documents, the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In mixed diet tests using rats that were applied with this substance (synthetic mineral), 4 or 7 mg/kg/diet, for 35 days, an increased fluorine content in the bone was measured, but this is not considered to be a health issue, and thus classification is not possible based on this result (IUCLID (2000)). With regard to Cryolite (natural mineral), workers who were exposed to 20 mg/m3 of this substance showed increased bone density, and those who were exposed for 2.5 years exhibited osteosclerosis (IUCLID (2000)). In addition, several cases of skeletal fluorosis were observed in those who underwent long-term exposure in the factory (IUCLID (2000)). Also, accumulation of fluoride in the bones were detected at all administered doses in the mixed diet tests using rats that were applied with 0 to 5000 ppm for 3 months (HSDB (2005)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 48-hour EC50 = 5.0 mg/L (IUCLID 2000) for crustaceans (Daphnia), the substance was classified into Category 2.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Its classification for acute toxicity is Category 2 and it is assumed not to be rapidly degradable as it is an inorganic substance. However, since its 96h EC0 = 5000 mg/L (IUCLID 2000), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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