GHS Classification Result

Chemical Name:methylenediphenyl diisocyanate
CAS:26447-40-5

Result:
ID: 20A2267
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Its autoignition point is > 600degC (IUCLID 2000), which is higher than 70degC.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since its rat LD50 is > 2000 mg/kg (OECD TG 401 GLP) (EU-RAR (2005)) and 31600 mg/kg (male) (CICADs No. 27 (2001)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since its rat LC50 values were 0.369 mg/L for males and 0.380 mg/L for females in 4-hour inhalation tests (EU-RAR 2005 of Final Report), the substance was classified into Category 2.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Since the rabbit Draize tests (OECD TG 406 GLP) resulted that scores for erythema, incrustation and edema peaked on day 7 (EU-RAR (2005)), it is considered to be a late-onset irritating substance. Because the average scores for erythema and incrustation were 2.33 after 72 hours and 3.17 after 7 days (EU-RAR (2005)), it is estimated that the average scores remained between 2.3 and 4.0 for 3 consecutive days. Based on these test results, the substance was classified into Category 2. According to the EU classification, the substance is rated as Xi; R36/37/38. The isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 2 (NITE, accessed in February 2009).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In rabbit tests, 5 out of 6 treated rabbits showed moderate conjunctivitis. While one rabbit who developed conjunctivitis also developed slight corneal epithelial abrasion, 4 other rabbits recovered from conjunctivitis after 6 days; from these results, the substance was concluded to be slightly irritating (EU-RAR (2005)). In addition, in Draize tests using female rabbits (OECD TG 405), the Draize score was 0 for all tested rabbits, concluding that the substance is not irritating (EU-RAR (2005)). These results indicate that the substance is considered to be only a slight irritant, if it is an irritant at all, and it is rated as Xi; R36/37/38 in the EU classification. Thus, the substance was classified into Category 2B. As relevant notes, the isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 2A-2B (NITE, accessed in February 2009).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible due to lack of data. The substance is rated as R42/43 in the EU classification, and its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 1 (NITE, accessed in February 2009).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
A maximization tests using female guinea pigs indicate that this substance is a strong allergen (EU-RAR 2005 of Final Report). Furthermore, the substance is rated as R42/43 in the EU classification. Based on this information, the substance was classified into Category 1. As relevant background information, its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is classified into Category 1 (NITE, accessed in February 2009).
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of data on either in vivo tests or in vitro mutagenicity tests using several indices. Regarding in vitro mutagenicity tests, positive results were acquired in Ames tests (EU-RAR (2005)) (NITE, accessed in February 2009).
6 Carcinogenicity Classification not possible - - - - The substance is rated as Carc. Cat. 3; R40 in the EU classification. Since no other classifications have been conducted by different classifying organizations and no tests have been carried out on this substance, it was classified into "Classification not possible". Its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), is rated as Group 3 by the IARC (IARC 71, 1999), and thus it is classified into "Not classified". (NITE, accessed in February 2009).
7 Reproductive toxicity Classification not possible - - - - No data available. Regarding the isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), clear reproductive toxicity was not found at the doses that cause general toxicity to parental animals in the tests using pregnant rats that underwent inhalation exposure (IARC 71, 1999; IRIS, 1998; CICAD 27, 2000). Thus, the isomer was classified into "Not classified". (NITE, accessed in February 2009).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available. Regarding the isomer of this substance, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), it is reported to cause respiratory irritation (DFGOT vol. 8, 1997; IARC 71, 1999), and is classified into Category 3 (respiratory tract irritation) (NITE, accessed in February 2009).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 14-day oral administration tests using rats, no effects of the substance on mortality or changes in body weight were detected at 2000 mg/kg (90-day conversion: 311 mg/kg), which is higher than Category 2 guidance doses (EU-RAR (2005)). However, since there are no reports on other symptoms, blood, biochemical examinations, or presence/absence of pathological cases, the substance was classified into "Classification not possible" due to insufficient data available. With respect to its isomer, methylenebis(4,1-phenylene) diisocyanate (CAS: 101-68-8), it has been classified into Category 1 (respiratory system) based on the results of inhalation exposure tests (NITE, accessed in February 2009).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its acute toxicity is > 100 mg/L for either algae, crustaceans or fish (EU RAR, 2005), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - This substance is known to polymerize after being hydrolyzed, and a polymer is not rapidly degradable and is considered to have low probability of accumulation. According to the GHS manual, this substance is not rapidly degradable (SRC: BioWin V4.10) and its logKow = 4.5 (EU RAR, 2005); in addition, since it is not identified as acutely toxic, it seems appropriate to place the substance into Category 4. However, there is little concern in terms of chronic toxicity since its 21-day NOEC for crustaceans (Daphnia magna) is > 10 mg/L (EU RAR, 2005) and its NOEC for algae and fish are > 1 mg/L; thus, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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