Chemical Name：alpha-cyano-3-phenoxybenzyl 2,2,3,3-tetramethylcyclopropanecarboxylate; fenpropathrin
CAS：39515-41-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on its rat LD50 values of 60 mg/kg bw and 164 mg/kg bw for male (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)) and 70 mg/kg bw and 107 mg/kg bw for female (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), the substance was classified into Category 3.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on its rat LD50 value of > 5000 mg/kg bw for both sexes, the substance was classified into "Not classified" (United Nations classification: "Not classified").
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Based on its rat LC50 value of > 0.072 mg/L for both sexes (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), classification is not possible because we cannot determine between Category 2 and "Not classified". (its saturated vapour pressure concentration is 0.000103 mg/L.)
2	Skin corrosion/irritation	Not classified	-	-	-	-	Since rabbit tests found that the substance is not irritating (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), it was classified into "Not classified".
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Since rabbit tests found that the substance causes mild irritation (although chemosis or congestion of the conjunctiva was observed and the substance was judged to be irritating, irritation was very mild and was virtually not problematic) (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)), the substance was classified into Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	Although negative results obtained in Buehler tests using rabbits (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)) indicated that the substance is to be placed into "Not classified" category, we classified it into "Classification not possible" because the results were generated using List 2 data.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Since in vivo micronucleus tests using mouse bone marrow gave negative results (Japan Crop Protection Association (Sumitomo Chemical 1989-II)), the substance was classified into the "Not classified" category. Regarding in vitro mutagenicity tests, both Ames tests and chromosomal aberration tests (using cultured Chinese Hamster ovarian cells) gave negative results (Japan Crop Protection Association (Sumitomo Chemical 1989-II)).
6	Carcinogenicity	Not classified	-	-	-	-	In 2-year oral administration tests using rats (CD strain) (male: 0, 1.93, 5.71, 17.06 and 22.8mg/kg/day; female: 0, 2.43, 7.23, 19.45 and 23.98mg/kg/day), tremors were detected as an effect severity of which was correlated with amount of exposure. Other effects related to the test substance or pathological abnormalities that severity was correlated with amount of exposure were not detected (IRIS (2002)). In joint chronic toxicity / carcinogenicity tests using rats (CD strain) (0, 50, 150, 450 and 600 ppm mixed diet), which is presumed to be the same as above-mentioned study, no consistent changes that were related to administration were not detected in hematological, blood biochemistry and histopathological examinations conducted. In addition, with regard to all tumors observed, rates of development were not different between control and treated groups; thus, the test was negative for carcinogenicity (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). Moreover, in 2-year oral administration tests using mice (male: 0, 3.9, 13.7 and 56mg/kg/day; female: 0, 4.2, 16.2 and 65.2mg/kg/day), any exposure-related toxicity was not detected other than marginally increased hyperactivity in female (IRIS (2002)). In combined chronic toxicity / carcinogenicity tests using rats (CD strain) (0, 40, 150 and 600 ppm mixed diet), which is presumed to be the same as above-mentioned study, no administration-related changes were observed in terms of either non-neoplastic or neoplastic changes inspected in histopathological examinations; thus, the test was negative for carcinogenicity (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). From this information, the substance was classified into the "Not classified" category.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In 2-generation oral administration tests using rats, no effects of exposure (at the concentrations (6.0 and 18 mg/kg/day) that induce parental toxicity) were detected using various parameters related to fertility such as pregnancy rate, birthrate and mating ratio; thus, there were no effects on fertility (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). On the other hand, in 3-generation oral administration tests, an increase in tremors and mortality was detected in F2b offspring at the exposure concentrations that cause parental toxicity, while there were no effects of exposure on reproductive toxicity (IRIS (2002)). In developmental toxicity tests using rats (from day 6 to day 15 of pregnancy: 0, 0.4, 1.5, 2, 3, 6 or 10 mg/kg/day), no skeletal malformations were detected at the exposure concentrations that cause parental toxicity, indicating that NOEL is higher than the highest concentration (10 mg/kg/day) tested (IRIS (2002)). In developmental toxicity tests using rabbits (from day 7 to day 19 of pregnancy: 0, 4, 12 or 36 mg/kg/day), no exposure related abnormalities or malformation were detected at the exposure concentrations that cause parental toxicity (IRIS (2002)). From this information, the substance was classified into Category 2 based on the results of 3-generation tests in that an increase in tremors and mortality was detected in offspring at the exposure concentrations that cause parental toxicity.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	In acute toxicity tests using rats, muscle cramp, tremors, atactic gait and irregular respiration were observed at the toxic dose (Pesticide Safety Information (Japan Crop Protection Association) (Sumitomo Chemical 1989-II)). Since the LD50 value is 60-164 mg/kg bw, it is presumed that muscle cramp, tremors, atactic gait and irregular respiration occurred at the exposure concentrations which fall under the range of Category 1 guidance values (<= 300 mg/kg bw). Although the substance is to be placed in Category 1 based on the guidance values, it was classified into Category 2 (nervous system) because the results were obtained using List 2 data.
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In 3-month oral administration tests using rats (0, 0.1, 0.5, 2.5 and 12.5 mg/kg/day), no exposure-related toxic effects were detected, and NOEL was found to be >= 12.5 mg/kg/day (IRIS (2002)). On the other hand, in 3-month oral administration tests using rats (0, 0.15, 1.5, 15 and 30 mg/kg-day), occurrence of tremors was detected during the fifth week after administration, and the symptom disappeared by Week 11 in female rats in the highest dose groups (30 mg/kg/day) (IRIS (2002)); and in 13-week oral administration tests using dogs (doses: 0, 250, 500 and 750 ppm (conversion values: 0, 6.25, 12.5 and 18.75 mg/kg bw/day)), occurrence of ataxia, tremors, lethargy and panting was observed. In particular, because tremors (IRIS (2002)) were detected at the dosage group equivalent to Category 2 guidance values (18.75 mg/kg bw /day), the substance was classified into Category 2 (nervous system). As relevant notes, in 13-week oral administration tests using dogs, low values were found in blood examination parameters (hematocrits, hemoglobin, and erythrocytes); and in inhalation tests using rats (no record of exposure time available), normocytic anemia, change in blood composition (e.g., TP, bilirubin, and cholesterol), and change in cholinesterase were documented (RTECS (2007)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 48-hour EC50 = 0.00053 mg/L for crustaceans (Daphnia magna) (AQUIRE, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Its classification for acute toxicity is Category 1 and it is not rapidly degradable (based on an estimated rapid degradability by BIOWIN), the substance was classified into Category 1.