GHS Classification Result

Chemical Name:metamitron; 4-amino-3-methyl-6-phenyl-1,2,4-triazin-5-one
CAS:41394-05-2

Result:
ID: 20A2276
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - The substance contains adjacent nitrogen atoms. Classification is not possible due to lack of data.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - The substance contains adjacent nitrogen atoms. Classification is not possible due to lack of data.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on its rat LD50 values of 2000 mg/kg bw (IUCLID (2000)) and 1447 mg/kg bw (RTECS (1997)), the substance was classified into Category 4. It is rated as R22 in the EU classification, which is equivalent to Category 3 or 4.
1 Acute toxicity (Dermal) Not classified - - - - Based on its rat LD50 values of > 4000 mg/kg bw (IUCLID (2000)) and > 500 mg/kg bw (RTECS (1997)), the substance was classified into "Not classified". It is unclear if it is rated as Category 5 in the United Nations classification.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Its rat LC50 is documented to be > 0.331 mg/L (IUCLID (2000)). Since its saturated vapour pressure is 7.0*10^-8 mg/L, the experiment was presumably conducted in dust / mist. As we are not able to determine where the substance is to be placed between Category 2 and the "Not classified" category, it was classified into "Classification not possible".
2 Skin corrosion/irritation Not classified - - - - It is documented that topical application of 500 mg of this substance on the forearm of 10 volunteers for 24 hours did not provoke any reactions (IUCLID (2000)). Rabbit tests also found that the substance causes no irritation (IUCLID (2000)). Thus the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - In rabbit tests, the substance was found to be not irritating (IUCLID (2000)). Thus, it was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Maximization tests using guinea pigs found that the substance is not sensitizing (IUCLID (2000)); however, no detailed information is available such as the ratio of animals tested. In addition, no other data are available. Thus, the substance was classified into "Classification not possible".
5 Germ cell mutagenicity Classification not possible - - - - No data available.
6 Carcinogenicity Classification not possible - - - - In 2-year oral administration tests using rats, no signs of carcinogenicity were detected (IUCLID (2000)). Also, in 87-week oral administration tests using mice, no signs of carcinogenicity were detected (IUCLID (2000)). Since neither study provided detailed information on these tests, the substance was classified into "Classification not possible" due to insufficient data available.
7 Reproductive toxicity Classification not possible - - - - In 3-generation reproductive toxicity tests using rats, no effects were found on reproductive performance or offspring at the dose of 300 ppm (conversion value: 15 mg/kg bw /day) (IUCLID (2000)). However, results related to administration of 100 ppm (conversion value: 5 mg/kg bw /day) and 1000 ppm (conversion value; 50 mg/kg bw /day) are not available. Regarding teratogenicity tests using rats or rabbits, the only description available is that no effects of administration was detected on embryotoxicity at the early development or teratogenicity (ICUCLID (2000)). Since necessary details on these studies are not provided, the substance was classified into "Classification not possible" due to insufficient data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Workers who produce formulations of this substance showed no health problems at the health checkup (IUCLID (2000)). In addition, agricultural workers (from 313 farms) who had used the formulation of this product for 3 years answered questionnaire surveys stating that they experienced no adverse effects caused by this substance. A clinical study was not carried out since specific effects of this substance were not known (IUCLID (2000)). Regarding animal tests; oral administration tests using rats, mice or dogs; dermal administration tests using rabbits, and inhalation tests using rats have been documented (IUCLID (2000)); however, there is no explanation on toxic symptoms and target organs. As such, the substance was classified into "Classification not possible" due to insufficient data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Its 7-day EC50 = 1.7 mg/L for aquatic plants (Lemna minor) (ECOTOX, 2008), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 2 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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