Chemical Name：myclobutanil; 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile
CAS：88671-89-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	There are six values of rat LD50 being documented (in g/kg bw): 1.75 (male), 1.80 (female), 1.6 (male), 2.29 (female) 2.62 (male), and 2.71 (female) (JMPR (1992)). Of these values, three fall into Category 4 and another three fall into "Not classified". Giving precedence to the more toxic category of two, the substance was classified into Category 4.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on two LD50 values for rabbits documented (> 5.0 g/kg bw is documented twice (JMPR (1992)), the substance was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	The classification is based on its rat LC50 of >=5.1 mg/L documented (JMPR (1992)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the report that the substance was found to be not irritating in rabbit tests (JMPR (1992)).
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Based on the report that the substance was found to be moderately to severely irritating (JMPR (1992)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Not classified	-	-	-	-	The classification is based on the report that the tests using guinea pigs gave negative results (JMPR (1992)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative results acquired in in vivo heritable mutagenicity tests using germ cells (dominant lethal tests using rats that underwent forced oral administration) (JMPR (1992)), and in vivo mutagenicity tests using somatic cells (chromosomal aberration tests using bone marrow of mice that underwent forced oral administration), the substance was classified into "Not classified". Regarding in vitro mutagenicity tests, both Ames tests and chromosomal aberration tests using cultured ovarian cells of Chinese hamsters gave negative results (JMPR (1992)).
6	Carcinogenicity	Not classified	-	-	-	-	In 2-year mixed diet administration tests using mice, enzymatic abnormalities related to the liver, histopathological alterations comprising centrilobular hypertrophy, periportal vacuolation were detected in the highest dose groups, while no signs of carcinogenicity were detected. In 24-month mixed diet administration tests using rats, enzymatic abnormalities related to the liver were observed in the highest dose groups during the experiment, a decreased weight and atrophy of testes were found in male rats in the highest dose groups, and abnormalities in convoluted seminiferous tubules were observed in microscopic examinations, while no signs of carcinogenicity were found in the highest dose groups (JMPR (1992)). Based on these reports, the substance was classified into "Not classified".
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In 2-generation mixed diet administration tests using rats, decreased number of births and pregnancies, and an increased number of stillbirths were observed in F0 and F1 generations in the highest dose groups; and atrophy of the prostate, decreased spermatozoa, necrotic spermatocytes of the epididymides, and atrophy of the testes were detected in male rats in the highest dose groups. In addition, oral administration tests were conducted during the organogenic period using either pregnant rats or pregnant rabbits. In either test, signs of maternal toxicity were observed in low dose groups, and an increased resorption, decreased fetal weight and increased rate of fetal mortality were also observed while no signs of teratogenicity were found (JMPR (1992)). Based on these reports, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In 3-month mixed diet tests using dogs, an increased liver weight, centrilobular or midzonal hepatocellular hypertrophy, enlargement of periportal hepatocytes, and chronic nephritis were observed at 1600 ppm (58.8 mg/kg/day), which falls under Category 2 guidance values (JMPR (1992)). Based on this report, the substance was classified into Category 2 (kidney). Additionally, in 3-month mixed diet administration tests, hepatic centrilobular hypertrophy and necrosis were detected at >= 1000 ppm (132 mg/kg/day for male and 232 mg/kg/day for female) in mice and at >= 3000 ppm (158 mg/kg/day for male and 195 mg/kg/day for female) in rats; in both studies, doses administered were above Category 2 guidance values (JMPR (1992)). It is speculated that these effects observed would be insignificant at doses within the range of Category 2 guidance values.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its 96-hour LC50 = 0.24 mg/L for crustaceans (mysids) (ECOTOX, 2008), the substance was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.