Chemical Name：(+/-) 2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl-1,1,2,2-tetrafluoroethylether
CAS：112281-77-3

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on its rat LD50 values of 1030 mg/kg for male rats and 1248 mg/kg for female rats (HSDB (2009)), the substance was classified into Category 4 using the JIS classification criteria (also Category 4 in the United Nations classification).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Not classified	-	-	-	-	The classification is based on negative results acquired in in vivo mutagenicity tests (micronucleus tests using mouse bone marrow cells) (HSDB (2009)). Regarding in vitro tests, both Ames tests and chromosomal aberration tests also gave negative results (HSDB (2009)).
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In 104-week mixed diet administration tests using rats, increased weights of the liver and kidney, centrilobular hepatocyte enlargement, and bile duct hyperplasia were detected in the highest dose groups, while no tumorigenesis developed. In addition, in 80-week mixed diet administration tests using mice, increases in both benign and malignant tumors in the livers, hepatocyte enlargement, granulomatous inflammation in the liver, bile duct hyperplasia, and increased incidence and/or severity of cortical scarring with atrophic tubules in the kidneys were detected at high and intermediate dose groups (HSDB (2009)). Based on these documents, the substance was classified into Category 2.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In two-generation mixed diet administration tests using rats, the following were observed in the highest dose groups: suppressed body weight gain in F0 males and F1A males and females; an increased liver weight in F0 and F1 males and females; a decreased litter size in F1 and F0; a decreased average body weight in F0, F1, and F1A offspring during the lactation period. In forced oral administration tests conducted during the organogenetic period using pregnant rats, suppressed body weight gain in maternal animals and decreased food consumption were detected; there were no effects on survival of fetuses; and hydroureter along with increased rates of 14th rib(s) formation were detected in fetuses in the highest dose groups. In mixed diet administration tests conducted during the oranogenetic period using rabbits there were no effects on body weight and food consumption in maternal animals, and the development of fetuses (HSDB (2000)). Based on these results, the substance was classified into Category 2 since reproductive toxicity is suspected.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In 4-week oral administration tests using rats, some abnormalities in blood biochemistry examinations and an increased liver weight were detected in 200 mg/kg groups. In 4-week mixed diet administration tests using rats, enlargement of centrilobular to midzonal hepatocytes in 160 ppm groups and above was noted; and vacuolization of centrilobular to midzonal hepatocytes in 2500 ppm groups was detected. In 13-week mixed diet administration tests using rats, an increased liver weight and enlargement of centrilobular hepatocytes were observed in both sexes treated at 360 ppm and in females treated at 60 ppm (which falls under Category 1 guidance values). In 13-week mixed diet administration tests using mice, severity and incidence of centrilobular hepatocyte enlargement increased in 25 ppm groups and above, and midzonal hepatocyte vacuolation were noted for the females in 625 ppm groups. Single cell necrosis in the liver was notable for the females in 125 ppm groups and for both sexes in 625 ppm groups. Single cell degeneration was noted in the livers of both sexes in 625 ppm and 125 ppm groups. In 21-day oral administration tests using rabbits, signs of irritation were observed only at the site of application. In 12-month mixed diet administration tests using dogs, the enlarged hepatocytes and cortical tubular hypertrophy were noted in 360 ppm groups (all results cited in HSDB (2009)). Based on these results, though they were obtained using List 2 datasets, the substance was classified into Category 1 (liver) as liver abnormalities appeared at the Category 1 guidance concentrations in rat and mouse studies.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.