GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Sodium arsenate
CAS：13464-38-5
Result：
| ID: | 20A2349 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solid | Not classified | - | - | - | - | Since sodium arsenate dibasic (CAS 7778-43-0, ID 20A2355) is not combustible (ICSC, 1999), we estimated that this substance is also non-combustible. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not combustible. Since sodium arsenate dibasic (CAS 7778-43-0, ID 20A2355) is not combustible (ICSC, 1999), we estimated that this substance is also non-combustible. |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible. Since sodium arsenate dibasic (CAS 7778-43-0, ID 20A2355) is not combustible (ICSC, 1999), we estimated that this substance is also non-combustible. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | It is stable in contact with water. (It is readily soluble in water according to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001).) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Given its substance-specific UN No. 1685, the substance is rated as Division 6.1, II; not Division 5.1, by the UNRTDG, which indicates oxidizing substances. Despite this information, due to lack of additional data, classification is not possible. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Since the LD50 for rats is 112 mg/kg (DFGOT 21, 2005), the substance was classified into Category 3. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Inorganic arsenic compounds are reported to cause irritation (DFGOT vol. 21, 2005). However, since no further information is available, classification is not possible. |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Since inorganic arsenic compounds are reported to irritate human eyes (HSG 70, 1992; PIM 042, 1996), this substance was classified into Category 2. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Not classified | - | - | - | - | Since this substance was not allergenic in the guinea pig maximization test (positive reaction rates: 0-8%) (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008); EHC 224 (2001)), it was classified into the "Not classified" category. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | In vitro tests (mouse lymphoma assays and transformation assays (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)) gave positive results. However, due to insufficient test results available, classification is not possible. According to MAK/BAT (2007), arsenic and its inorganic compounds are classified into Category 3A for germ cell mutagenicity (which is equivalent to Category 1B to 2 in the GHS classification). |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
According to IARC Suppl. 7 (1987), ACGIH-TLV (2008), and MAK/BAT (2007), arsenic and its inorganic compounds are categorized as human carcinogens. Thus, the substance was classified into Category 1A. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Hamsters that received intravenous administration (EHC 224, 2001) and mice that underwent intraperitoneal administration (Initial Risk Assessment Report (NITE, CERI, NEDO) (2008)) showed signs of developmental toxicity (increased incidences of malformations in the neural tube). In addition, according to description for arsenic and arsenic compounds documented in EHC 224 (2001) which is a List 1 information source, these substances are suggested to affect human reproduction (increased fetal, neonatal and postnatal mortality, spontaneous abortions, and congenital malformations, etc.) and have teratogenic effects at doses that are toxic to maternal animals. Thus, the substance was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, liver) |
|
Danger | H370: Causes damage to organs (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, liver) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Nephrotoxic effect was seen in a dog that underwent intravenous administration (EHC 224, 2001). In humans, the following acute toxic effects by arsenic compounds are documented: symptoms of the gastrointestinal tract, cardiovascular system, nerves, and blood system; conjunctivitis and dermatitis as well as irritation to the nasal mucosa, pharynx, and trachea; frequent urination or anuria due to a blockage of renal tubules with clots of hemoglobin (IARC 23 (1980)); depression of bone marrow functions; and hepatomegaly (EHC 224 (2001)). In accordance with these reports, the digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver were considered to be target organs of these compounds, and this substance was classified into Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Alterations in kidney and liver were observed in rats exposed to this substance (dose: approx. 4 mg/kg bw/day) repeatedly for 320 days (EHC 224, 2001; Initial Risk Assessment Report (NITE, CERI, NEDO), 2008). In addition, according to EHC 224 (2001) on arsenic and its inorganic compounds in relation to humans, gastrointestinal tract disorder; nervous disorder; effects on the blood system; and abnormalities in cardiovascular system, kidney, and liver were observed. Thus, target organs for these substances are the gastrointestinal tract, heart, brain, and kidney. In addition, the skin, bone marrow and peripheral nervous system are also affected by these substances. Moreover, according to ACGIH (2001), the upper respiratory tract and lung are also affected. Based on these reports, this substance was classified into Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, and skin). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | - | - | - | - | - | - |
| 11 | Hazardous to the aquatic environment （Long-term） | - | - | - | - | - | - |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |