GHS Classification Result (Revision of the past classification result)

Chemical Name:Arsenic pentachloride
CAS:22441-45-8

Result:
ID: 20A2351
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
2 Flammable gases (including chemically unstable gases) Classification not possible - - - - It is estimated to be not combustible due to its composition. However, due to lack of test results, classification is not possible.
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
5 Gases under pressure Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. At extremely low temperatures (-50degC or so), the substance is presumably stable in a liquid state. Since no information on the critical temperature is available, we cannot determine if the substance is a high-pressure liquefied gas or low-pressure liquefied gas.
6 Flammable liquids Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
7 Flammable solid Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
8 Self-reactive substances and mixtures Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
9 Pyrophoric liquids Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
10 Pyrophoric solids Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
13 Oxidizing liquids Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
14 Oxidizing solids Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
15 Organic peroxides Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.
16 Corrosive to metals Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
2 Skin corrosion/irritation Classification not possible - - - - No data available. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No test results are available on this substance. Although inorganic arsenic compounds may cause skin sensitization in humans, this is not a definitive conclusion (ATSDR, 2007; HSG, 1992). According to EHC 224 (2001), dermal sensitization to inorganic arsenic appears to be a rare occurrence in humans. Overall, due to insufficient study results available, the substance was classified into the "classification not possible" category. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
5 Germ cell mutagenicity Classification not possible - - - - No data available. The DFG in Germany has classified arsenic and its inorganic compounds into Category 3A for germ cell mutagenicity (which is equivalent to Category 1B to 2 in the GHS classification) (MAK/BAT, 2007). According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
According to IARC Suppl. 7 (1987), ACGIH-TLV (2008), and MAK/BAT (2004), arsenic and its inorganic compounds are categorized as human carcinogens. Thus, the substance was classified into Category 1A. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
No test results on this substance were found, but according to description for arsenic and arsenic compounds documented in EHC 224 (2001) which is a List 1 information source, these substances are suggested to affect human reproduction and have teratogenic effects at doses that are toxic to maternal animals. Thus, the substance was classified into Category 2. As additional background information, the Catalog of teratogenic agents (2004), which is equivalent to List 1 sources, supports the conclusion that inorganic arsenic is not teratogenic to humans. According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, liver) Danger H370: Causes damage to organs (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
No test results were found on single exposure to this substance other than lethal effects. In humans, the following acute toxic effects by arsenic compounds are documented: symptoms of the gastrointestinal tract, cardiovascular system, nerves, and blood system; conjunctivitis and dermatitis as well as irritation to the nasal mucosa, pharynx, and trachea; frequent urination or anuria due to a blockage of renal tubules with clots of hemoglobin (IARC 23 (1980)); depression of bone marrow functions; and hepatomegaly (EHC 224 (2001)). In accordance with these reports, the digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver were considered to be target organs of these compounds, and this substance was classified into Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver). According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
9 Specific target organ toxicity - Repeated exposure Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
No test results on repeated exposure to this substance were found. According to EHC 224 (2001) on arsenic and its inorganic compounds in relation to humans, gastrointestinal tract disorder; nervous disorder; effects on the blood system; and abnormalities in cardiovascular system, kidney, and liver were observed. Thus, target organs for these substances are the gastrointestinal tract, heart, brain, and kidney. In addition, the skin, bone marrow and peripheral nervous system are also affected by these substances. Moreover, according to ACGIH (2001), the upper respiratory tract and lung are also affected. Based on these reports, this substance was classified into Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, and skin). According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.
10 Aspiration hazard Classification not possible - - - - According to the manual for handling poisonous and hazardous substances (Jiji Press, latest version, 2001), the substance starts decomposing at -25degC; so the substance is presumably in an unstable state at room temperature. See arsenic trichloride (CAS 7784-34-1, ID 20A2342) and chlorine (CAS 7782-50-5, Japanese government's classification ID 570), which are byproducts of the decomposition of arsenic pentachloride.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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