GHS Classification Result (Revision of the past classification result)

Chemical Name:Arsenic(V) fluoride
CAS:7784-36-3

Result:
ID: 20A2357
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Not classified - - - - It is not combustible (BGIA, GESTIS-database on hazardous substance, accessed in December 2008).
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Classification not possible - - - - No data available.
5 Gases under pressure Compressed gas or Liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Its boiling point is -53.2degC (Merck, 13th, 2001). Since information on its critical temperature is not available, we cannot determine if the substance is a compressed gas or liquefied gas.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solid Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gaseous substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible - - - - Inorganic arsenic compounds are reported to cause irritation (DFGOT vol. 21, 2005). However, since no further information is available, classification is not possible.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Since inorganic arsenic compounds are reported to irritate human eyes (HSG 70, 1992; PIM 042, 1996), this substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No test results are available on this substance. Although inorganic arsenic compounds may cause skin sensitization in humans, this is not a definitive conclusion (ATSDR, 2007; HSG, 1992). According to EHC 224 (2001), dermal sensitization to inorganic arsenic appears to be a rare occurrence in humans. Overall, due to insufficient study results available, the substance was classified into the "classification not possible" category.
5 Germ cell mutagenicity Classification not possible - - - - No data available. The DFG has classified arsenic and its inorganic compounds into Category 3A for germ cell mutagenicity (which is equivalent to Category 1B to 2 in the GHS classification) (MAK/BAT, 2007).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
According to IARC Suppl. 7 (1987), ACGIH-TLV (2008), and MAK/BAT (2007), arsenic and its inorganic compounds are categorized as human carcinogens. Thus, the substance was classified into Category 1A.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
No test results on this substance were found, but according to description for arsenic and arsenic compounds documented in EHC 224 (2001) which is a List 1 information source, these substances are suggested to affect human reproduction and have teratogenic effects at doses that are toxic to maternal animals. Thus, the substance was classified into Category 2. As additional background information, the Catalog of teratogenic agents (2004), which is equivalent to List 1 sources, supports the conclusion that inorganic arsenic is not teratogenic to humans.
8 Specific target organ toxicity - Single exposure Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, liver) Danger H370: Causes damage to organs (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
No test results were found on single exposure to this substance other than lethal effects. In humans, the following acute toxic effects by arsenic compounds are documented: symptoms of the gastrointestinal tract, cardiovascular system, nerves, and blood system; conjunctivitis and dermatitis as well as irritation to the nasal mucosa, pharynx, and trachea; frequent urination or anuria due to a blockage of renal tubules with clots of hemoglobin (IARC 23 (1980)); depression of bone marrow functions; and hepatomegaly (EHC 224 (2001)). In accordance with these reports, the digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver were considered to be target organs of these compounds, and this substance was classified into Category 1 (digestive system, circulatory system, nervous system, blood system, respiratory system, skin, kidney, and liver). In addition, fluoride is also reported to irritate the respiratory tract (ACGIH-TLV, 2008; ACGIH, 2001).
9 Specific target organ toxicity - Repeated exposure Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin, bone) Danger H372: Cause damage to organs through prolonged or repeated exposure (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin, bone) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
No test results on repeated exposure to this substance were found. According to EHC 224 (2001) on arsenic and its inorganic compounds in relation to humans, gastrointestinal tract disorder; nervous disorder; effects on the blood system; and abnormalities in cardiovascular system, kidney, and liver were observed. Thus, target organs for these substances are the gastrointestinal tract, heart, brain, and kidney. In addition, the skin, bone marrow and peripheral nervous system are also affected by these substances. Also, according to ACGIH (2001), the upper respiratory tract and lung are also affected. Furthermore, fluoride is reported to irritate the respiratory tract and affect bones (fluorosis) (ACGIH-TLV, 2008; ACGIH, 2001). Based on these reports, this substance was classified into Category 1 (digestive system, circulatory system, nervous system, kidney, liver, blood system, respiratory system, skin, and bone).
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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