GHS Classification Result （Revision of the past classification result）

Chemical Name：Nickel(II) sulfide
CAS：16812-54-7

Result：
ID: 20A2371
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is stable in contact with water (it is insoluble in water (Lide 84th, 2003)).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen atoms
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Nickel and its compounds are rated as respiratory tract sensitizers (Group 2) in the Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, they are rated as respiratory tract sensitizers by the DFG (MAK/BAT No. 43 (2007)). Based on these ratings, the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Nickel and its compounds are rated as skin sensitizers (Group 1) in the Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, they are rated as skin sensitizers by the DFG (MAK/BAT No. 43 (2007)). Based on these ratings, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible due to lack of in vivo test results available. As additional background information, mutation tests using CHO cells, V79 cells, or CHOAS52 cells gave positive results (IARC 49 (1990); ATSDR (2005)), and chromosomal aberration tests using FM3A cells, Chinese hamster embryo cells, or CHO cells also gave positive results (IARC 49 (1990); EHC No. 108 (1991)).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Nickel compounds are rated as "Group 1" by the IARC (IARC 49 (1990)), "Group 1" by Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits (2005)), "K" by the NTP (NTP RoC (11th, 2005)), and "Category 1" by the EU. In addition, insoluble nickel compounds are rated as "A1" by ACGIH (ACGIH 7th, 2001). Based on these ratings, the substance was classified into Category 1A. As additional background information, seven separate carcinogenicity tests using rats that underwent intramuscular injection detected the development of local sarcomas (rhabdomyosarcomas) (EHC No. 108 (1991), ECETOC TR No. 33 (1989)). In addition, one test in which rats received intrarenal injection of this substance found a significant and marked increase in renal cancers (IARC vol. 49 (1990)).
7 Reproductive toxicity Classification not possible - - - - No data available. See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available. See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available. See also health hazards associated with other nickel compounds (Nickel(II) chloride and nickel sulfate, etc.).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information