GHS Classification Result （Revision of the past classification result）

Chemical Name：Nickel sulfate
CAS：7786-81-4

Result：
ID: 20A2373
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Not combustible (ICSC (2004))
8 Self-reactive substances and mixtures Classification not possible - - - - No data available.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - It is not combustible (ICSC (2004)) and does not ignite spontaneously in contact with air at room temperature.
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (2004))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is a metal compound, its water solubility is 40.4 g/100 g at 25degC (Lide (88th, 2008)), and it is stable in contact with water.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - It is an inorganic compound containing oxygen, which is bonded to nickel and sulfur. Since no further information is available, classification is not possible.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Its rat LD50 values are documented to be 46 mg/kg for male and 39 mg/kg for female (which fall under Category 2) (ATSDR (2005)), 500 mg/kg (which falls under Category 4) (ECETOC TR 33 (1989)), 275 mg/kg (which falls under Category 3) (ECETOC TR 33 (1989)), 325 mg/kg (which falls under Category 4) (ECETOC TR 33 (1989)). Choosing a category that represents the majority of the results, the substance was classified into Category 4
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Although rabbit Draize tests have been documented (RTECS (2008)), no test results are provided. Thus, classification is not possible due to lack of data. It is rated as R38 and Xi in the EU classification.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		It is rated as R42/43 in the EU classification. In addition, Nickel and its compounds are categorized into respiratory tract sensitizers (Group 2) in Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, they are rated as respiratory tract sensitizers by the DFG (MAK/BAT No. 43 (2007)). Based on these ratings, the substance was classified into Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Among 4140 cases having suspected to be of contact allergic atopic dermatitis, 23.8% of female and 5.2% of male showed sensitivity to nickel (DFGOT vol. 22 (2006)). The substance is rated as R42/43 in the EU classification. In addition, Nickel and its compounds are categorized into skin sensitizers (Group 1) in Recommendations of Occupational Exposure Limits (Japan Society for Occupational Health, 2008). Similarly, they are rated as skin sensitizers by the DFG (MAK/BAT No. 43 (2007)). Based on these information, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Since the following in vivo studies produced negative results, the substance was classified into the "Not classified" category: in vivo chromosomal aberration tests using rat spermatogonial cells (in vivo germ cell mutagenicity tests) (EHC 108 (1991)), chromosomal aberration tests using mouse bone marrow cells, and micronucleus assays using peripheral blood (in vivo mutagenicity tests using somatic cell) (EHC 108 (1991)). Regarding in vitro mutagenicity tests, Ames tests gave negative results (EHC 108 (1991)), mutation tests using V79 cells gave positive results (IARC 49 (1990)), and mouse lymphoma assays gave weakly positive results. (EHC 108 (1991)).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is rated as "Group 1" by the IARC (IARC 49 (1990)), "Category 1" by the EU (EU-Annex 1 (2009)), "Group 1" by Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits (2008)), and "K" by the NTP (NTP RoC (11th, 2005)). Based on these ratings, the substance was classified into Category 1A. In addition, soluble inorganic nickel is rated as "A4" by ACGIH (ACGIH-TLV (2008)) and "D" by the EPA (IRIS (1991)).
7 Reproductive toxicity Classification not possible - - - - In 2-generation reproduction toxicity tests using rats that received oral administration, pathological changes in the reproductive organs, or any effects on fertility and sexual functions were not noted (ATSDR (2005)) in either sex. Likewise, other reproduction toxicity tests using rats that received oral administration found no effects on fertility or reproductive functions. However, since test results on developmental toxicity to offspring are insufficient, the substance was classified into the "Classification not possible" category. See also health hazards associated with other nickel compounds (e.g., Nickel(II) chloride).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In the inhalation test using rats, hemorrhage of the lungs was observed at the dose of 36.5 mg Ni/m3 (= 0.037 mg/L/2h; 4-hour conversion: 0.018 mg/L/4h), which falls under Category 1 guidance values (ATSDR (2005)). However, since severity of the hemorrhage is unknown and no other study results are available, the substance was classified into the "Classification not possible" category. See also health hazards associated with other nickel compounds (e.g., Nickel(II) chloride).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, male genitalia) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, male genitalia) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 13-week inhalation exposure tests using rats, chronic active inflammation of the lung and neutrophilia were observed at > 0.00006 mg Ni/L for female rats, and 0.00022 and 0.0004 mg Ni/L for male rats; also, lymphocytosis, hyperplasia of the lymph node, and atrophy of the olfactory epithelium were observed at 0.0004 mg Ni/L in both sexes (NTP TR 454 (1996)). Similarly, 2-year inhalation exposure tests using rats detected pulmonary lesion such as inflammation and fibrosis of the lung at the doses of 0.00006 mg Ni/L and/or 0.0001 mg Ni/L in both sexes (at 7-month and 15-month interim evaluation and the end of study), and hyperplasia of the lymph node and atrophy of the olfactory epithelium were also noted at 0.0005 mg/L in both sexes at the end of the experiment (NTP TR 454 (1996)). Since these doses fall under Category 1 guidance values, and lesions of the nasal cavity and lung were observed, the substance was classified into Category 1 for its toxic effects on the respiratory system. In addition, in 120-day oral administration tests using male rats, effects on the testes were noted at 25 mg Ni/kg, which falls under Category 2 guidance values; and in 35-day oral administration tests using male mice, atrophy of the seminal vesicles, epididymis, and central part of the vas deferens were observed at 1.1 mg Ni/kg, which falls under Category 1 guidance values. Thus, the substance was also classified into Category 1 for its toxic effects on male genitalia. See also health hazards associated with other nickel compounds (e.g., Nickel(II) chloride).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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