GHS Classification Result （Revision of the past classification result）

Chemical Name：1,2-Dichloropropane
CAS：78-87-5

Result：
ID: 20A2375
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point is 16degC (closed cup) according to the ICSC (2000) and its boiling point is 96degC. Based on this information, the substance falls under Category 2. It is rated as Class 3 and packing group II by the UNRTDG (UN No. 1279).
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - It does not spontaneously ignite in contact with the air at room temperature (autoignition point: 557degC (ICSC, 2000)).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen or fluorine), which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available. It is rate as Class 3 by the UNRTDG (UN No. 1279).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the oral LD50 of 1900 mg/kg for the rat (EHC 146 (1993)), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Based on the dermal LD50 of 10115 mg/kg for the rabbit (DFGOT vol. 9 (1998)), the substance was classified into the "Not classified" category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - It was classified into the "Not applicable" category since it is a liquid (GHS definition), and it is presumably not inhalable as a gas.
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - The 10-hour LC50 of 14 mg/L for rats obtained in vapour inhalation exposure test (PATTY 5th (2001)) is converted to 4-hour LC50 of 35 mg/L (7600 ppm). Given that its saturated vapour pressure is 7.1 kPa at 25degC (HSDB (2005)), its saturated vapour pressure concentration is 70000 ppm. As the LC50 value obtained above is lower than 90% of the saturated vapour pressure concentration, the test was presumably conducted in a vapour with almost no included mists. Under this condition, the substance was classified into the "Not classified" category using the ppm concentration criteria.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		The substance was classified into Category 2 since it was considered to be irritating based on the results of the skin irritation test using rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005)) and the report on the effect of the substance on humans (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 2 (2003)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The substance was classified into Category 2A since it was considered to be a reversible and moderate irritant based on the results of the eye irritation test using rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005)) and the report on the effect of the substance on humans (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 2, 2003; Patty, 1995).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The substance was classified into Category 1 since it is considered to be a skin sensitizer based on the report on two human cases (EHC 146 (1993)).
5 Germ cell mutagenicity Not classified - - - - It was classified into the "Not classified" category since heritable mutagenicity test (dominant lethal test using rats) gave negative results according to Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In carcinogenicity tests through inhalation, an increase in the frequency of intranasal tumors was observed in both female and male rats, supporting the evidence that the test substance is carcinogenic. Similarly, an increase in the frequency of Harderian gland adenomas was noted in male mice, suggesting the evidence that the substance is carcinogenic to male mice. In addition, an increase in the frequencies of bronchiolar / alveolar carcinomas in female mice was noted, indicating that the substance is carcinogenic to female mice (Ministry of Health, Labour and Welfare (Results from Carcinogenicity Studies), 2005). On the other hand, carcinogenicity tests through oral administration using rats found no clear increase in the frequency of tumors was noted. Overall, carcinogenicity studies using mice that received oral administration resulted in an increase in the frequencies of hepatic adenomas and liver carcinomas, which supports the evidence that there is a neoplastic response in the mouse liver for both sexes (NTP TR 263, 1988). Thus, the substance was classified into Category 2. The substance is rated as "Group 3" in IARC 71 (1999) and "A4" in ACGIH-TLV (2001), but these assessments did not take into account studies led by the Ministry of Health, Labour and Welfare.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a 2-generation test using rats, decreased body weight in neonates at birth and increased mortality of neonates were noted at the concentrations that affected parental animals (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005)). Based on these results, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (liver, blood, kidney), Category 3 (respiratory tract irritation, narcotic effects) Danger
Warning 		H370: Causes damage to organs (liver, blood, kidney)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Clinical signs of being exposed to this substance included shock, delirium, cardiovascular collapse, resulting death in 36 hours. Autopsy confirmed hepatic necrosis (ACGIH, 2006) and acute tubular necrosis (EHC 146 (1993)). Exposed people also experienced fatigue, possibly attributed to CNS depression (ATSDR (1989)). In animal experiments, respiratory tract irritation (ACGIH, 2006), labored breathing, hypomopbility, and coma were observed (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005)). Based on these reports, the liver, blood system, and kidney were considered as target organs, and the substance was linked to respiratory tract irritation and narcotic effects. Overall, the substance was classified into Category 1 for the liver, blood system, and kidney, and Category 3 for respiratory tract irritation and narcotic effects.
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney, liver, blood system), Category 2 (respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (kidney, liver, blood system)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		The substance is associated with hemolytic anemia and dysfunction of the liver and kidney in humans (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005), ACGIH, 2006). In animal studies, the kidney, liver, blood system, and respiratory system were considered to be target organs based on the report that the substance is related to degeneration of the olfactory epithelium (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005)). Based on these reports, the kidney, liver, blood system, and respiratory system were considered to be the target organs. In animal studies, these effects were observed at Category 2 guidance doses. In conclusion, the substance was classified into Category 1 for the kidney, liver, and blood system, and Category 2 for the respiratory system.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information