GHS Classification Result

Chemical Name：Triethyl phosphite
CAS：122-52-1

Result：
ID: 21A3505
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 3 since flash point 54 degC (closed-cup) (ICSC (1997)) is >=23 degC and <=60 degC. The substance is classified into Class 3, PG III in UNRTDG (UN2323).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 250 degC (Hommel (1996), HSDB (2007)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - The substance is an organic compound containing metalloids (P) and is quickly hydrolyzed (SIDS (2003)). Further, it is classified into Class 3, PG III in UNRTDG (UN2323). The substance is classified into Not classified since it is not classified into upper Division 4.3 (Substances which in contact with water emit flammable gases) from the Precedence of hazards Table.
13 Oxidizing liquids Not classified - - - - Flammable liquid
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - LD50 values are >2385 mg/kg bw (male), 1840 mg/kg bw (female), 2470 mg/kg bw (male) and 4000 mg/kg bw for rats (SIDS (2003)). Since one value corresponds to Category 4 and three values correspond to "Not classified" in JIS Classification (correspond to Category 5 in GHS classification), the substance was classified as "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of 2800 mg/kg bw (male) and >3000 mg/kg bw (female) for rabbits (SIDS (2003)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on LC50 values of 11.6 mg/L/6h (14.2 mg/L/4h) (male) and 11.1 mg/L/6h (13.6 mg/L/4h) (female) for rats (SIDS (2003)), the substance was classified as "Not classified". Since the saturated vapour pressure concentration of the substance is 25 mg/L, the test was considered to be conducted for mist from the report of the aerosol in the assessment document.
2 Skin corrosion/irritation Not classified - - - - Based on results of "slightly irritating" (PDII: 1.4) in a rabbit test (OECD TG404) (SIDS (2003)) and "mildly irritating" (PDII: 1.7) in another rabbit Draize test (SIDS (2003)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		In a rabbit test (OECD TG405), the substance was considered "slightly irritating" since 3/3 animals showed erythema and 2/3 animals showed chemosis within 1-hour, however the effects were completely reversible within 48-hour. No effects were observed in the cornea or iris (SIDS (2003)). In another rabbit Draize test, the substance was considered "moderately irritating" since irritating effects were observed within one day after application and were more severe after washing with water. The effects were completely reversible within 48-hour (SIDS (2003)). Based on the results of these two tests, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a result of "sensitizing" in a guinea pig maximization test (OECD TG406) where the positive ratio was 95% (19/20) (SIDS (2003)), the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on a negative result in an intraperitoneal injection mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (SIDS (2003)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there is a report of a negative Ames test (SIDS (2003)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on results of a reproduction/developmental toxicity screening test by oral administration to rats (OECD TG421), fertility and developmental toxicities were found as evidenced by severely reduced pup survival, increase in time to insemination, severely reduced gestation rate, and increase in stillbirths and dead pups at a dose level at which decreased body weight gain and general signs such as hypoactivity and piloerection were observed in parent animals (SIDS (2003)). The substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was reported that respiratory tract irritation, if severe, can progress to pulmonary edema in some cases of human health effects (HSDB (2007)). In a oral acute toxicity test in rats (dose level: 1000 to 4000 mg/kg), rapid breathing was observed prior to death, with most deaths occurring within 24-hour of dosing. LD50 values were determined to be 1840 mg/kg (female) and 2470 mg/kg (male) (SIDS (2003)). Additionally, in a rat acute inhalation (aerosol) toxicity test, upper respiratory irritation and rapid shallow breathing occurred. Most deaths occurred within 24-hour following treatment, and lung congestion was observed at necropsy at a dose level exceeding the guidance value range of Category 2 (SIDS (2003)). The effects by oral exposure to rats were observed at dose levels within the guidance value range for Category 2 (<=2000 mg/kg). The results of the inhalation test suggests strong effect on the respiratory system. Based on the report of human effects as reported in a document in List 2, the substance was classified into Category 2 (respiratory system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a repeat dose toxicity test with oral dosing to rat for 32 days (OECD TG407), the NOAEL of 150 mg/kg/day (90-day equivalent: 53.3 mg/kg/day) determined is within the guidance value range. At a higher dose rate of 750 mg/kg/day (90-day equivalent: 266.7 mg/kg/day), mortality, inflammatory changes, fibrosis and hyperplasia of bronchial epithelium in the lung and changes in blood parameters indicative of a stimulation in erythropoiesis were observed (SIDS (2003)). The higher dose exceeds the guidance value range, therefore classification was not possible due to lack of data for evidence of effects at or near the upper limit (100 mg/kg/day) guidance value range.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 24h-EC50 = 94.1 mg/L for Crustacea (Daphnia magna) (SIDS, 2005).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since it is rapidly degradable (decomposition by OECD TG301E: 69% (SIDS, 2005)) and bioaccumulation potential of its hydrolysates in estimated to be low (SIDS, 2005) though its acute toxicity is Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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