Chemical Name:3,4-Dimethylaniline
CAS:95-64-7
ID: | 21A3511 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2009 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Auto-ignition point is 580 degC (ICSC (2007)) exceeding 70 degC. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Classification is not possible since no data are available though the substance is a solid (melting point <=55 degC). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on LD50 values of 810 mg/kg (ACGIH (2002)) and 707 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)) for rats, the substance was classified into Category 4. | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Chinese hamster CHL/IU cell chromosomal aberration test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2009)) and a negative without metabolic activation but a positive for some strain with metabolic activation in Ames tests (NTP DB (access on June 2009)). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data on the substance alone. In a mouse 18-month feeding test with 2,4-xylidine which is an isomer, there were no increased tumor incidences in male mice but the females of the high-dose group had a significantly increased number of lung tumors (ACGIH (2002)). In a rat two-generation (104 weeks after weaning for F1) feeding test with 2,6-xylidine, there were significant increases in the incidences of adenocarcinomas or carcinomas of the nasal cavity (ACGIH (2002)). Therefore, xylidine (mixed isomers) (CAS No. 1300-73-8) is classified into "A3" in ACGIH. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood system) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on a report suggesting effects on blood system such as changes in hematological factors, black and enlargement of the spleen, increased hematopoiesis (both sexes) at the high-dose (250 mg/kg/day, 90-day equivalent: 77.8 mg/kg/day) level in a rat 28-day oral administration test (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)), the substance was classified into Category 2 (blood system). As relevant information, there are results that a methemoglobine level of 27% and a Heinz body formation ratio 76% were induced by inhalation exposure of mixed isomers to cats for at least 44 weeks (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 2 from its 48h-EC50 = 1.1 mg/L for Crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2004). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 7.1% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1978)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
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