GHS Classification Result

Chemical Name:3,4-Dimethylaniline
CAS:95-64-7

Result:
ID: 21A3511
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Auto-ignition point is 580 degC (ICSC (2007)) exceeding 70 degC.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Classification is not possible since no data are available though the substance is a solid (melting point <=55 degC).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on LD50 values of 810 mg/kg (ACGIH (2002)) and 707 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)) for rats, the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Chinese hamster CHL/IU cell chromosomal aberration test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (2009)) and a negative without metabolic activation but a positive for some strain with metabolic activation in Ames tests (NTP DB (access on June 2009)).
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data on the substance alone. In a mouse 18-month feeding test with 2,4-xylidine which is an isomer, there were no increased tumor incidences in male mice but the females of the high-dose group had a significantly increased number of lung tumors (ACGIH (2002)). In a rat two-generation (104 weeks after weaning for F1) feeding test with 2,6-xylidine, there were significant increases in the incidences of adenocarcinomas or carcinomas of the nasal cavity (ACGIH (2002)). Therefore, xylidine (mixed isomers) (CAS No. 1300-73-8) is classified into "A3" in ACGIH.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on a report suggesting effects on blood system such as changes in hematological factors, black and enlargement of the spleen, increased hematopoiesis (both sexes) at the high-dose (250 mg/kg/day, 90-day equivalent: 77.8 mg/kg/day) level in a rat 28-day oral administration test (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)), the substance was classified into Category 2 (blood system). As relevant information, there are results that a methemoglobine level of 27% and a Heinz body formation ratio 76% were induced by inhalation exposure of mixed isomers to cats for at least 44 weeks (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 2 from its 48h-EC50 = 1.1 mg/L for Crustacea (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2004).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Non-biodegradable, BOD degradation rate: 7.1% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1978)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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