GHS Classification Result

Chemical Name：2-Aminoanthraquinone
CAS：117-79-3

Result：
ID: 21A3513
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (room temperature)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (room temperature)
5 Gases under pressure Not applicable - - - - Solid (room temperature)
6 Flammable liquids Not applicable - - - - Solid (room temperature)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (room temperature)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Not classified - - - - Not self-heating (IUCLID 2000)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (room temperature)
14 Oxidizing solids Not classified - - - - Not enhancing combustion (IUCLID 2000)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on a LD50 value of >36 g/kg bw for rats (IARC 27 (1982)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (room temperature)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on a result of "not irritating" in rabbit test (IUCLID (2000)).
3 Serious eye damage/eye irritation Not classified - - - - Based on a report of "not irritating" in a rabbit test (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of negative and positive Ames tests (NTP DB (access on Jul. 2009), IUCLID (2000)), and a positive CHO cell chromosomal aberration test (NTP DB (access on Jul. 2009)). In addition, the substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Not classified - - - - Based on the classification of "Group 3" in IARC (IARC 27 (1982)), the substance was classified as "Not classified". However, the substance was classified into "B" in NTP ROC (NTP ROC No.11 (2005)) based on the conclusion that it is considered to be a carcinogen for rats and mice as there was an increased incidence of hepatocellular carcinomas and malignant lymphomas for mice, and hepatocellular carcinomas and neoplastic nodules of the liver for rats in 78-week feeding test followed by a 15 - 16-week (mice) or 28 - 32-week (rats) post-treatment observation periods (NTP TR144 (1978)). IARC considered above test as "limited evidence for the carcinogenicity in experimental animals due to the low purity the material tested" and concluded "In view of the uncertain purity of the compound tested and in the absence of data on humans, no evaluation of the carcinogenicity could be made". IARC then classified the substance into "Group 3" (IARC 27 (1982)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there is a report that in a four week feeding test in rats and mice receiving 1 - 4% in the diet, reductions in weight gain were observed (IARC 27 (1982)), the detailed data are not clear. Additionally, in a 12 - 14 weeks feeding test with rats receiving 1% or 2% in the diet (830 or 1670 mg/kg), females experienced weight loss, emaciation, ataxia, convulsions. All females died within 18 and 21 weeks. Hematological and blood biochemical changes, histopathological findings of kidney damage such as interstitial fibrosis and multitudinous tubular metaplasia as well as bone marrow hyperplasia were observed (IUCLID (2000)).These dose levels exceeded the guidance value range. Therefore classification was not possible due to lack of data for evidence of effects at or near the upper limit of the guidance value range.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Classified into Not classified from its 96h-LC50 >10000 mg/L for fish (Golden orfe) (AQUIRE, 2010), 48h-EC50 >378 mg/L for Crustacea (Daphnia magna) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since it is non-water soluble (water solubility = 0.163 mg/L (PHYSPROP Database, 2009) and its low bioconcentration potential is estimated (BCF = 18 - 46 (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1989)) without acute toxicity value at or lower concentration than water solubility (AQUIRE, 2010; IUCLID, 2000).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information