GHS Classification Result

Chemical Name：3-Methylbutanal
CAS：590-86-3

Result：
ID: 21A3520
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 2 since flash point -5 degC (Hommel (1996)) is <23 degC and initial boiling point 92.5 degC (Ullmanns (E) (2003)) is >35 degC. The substance is classified into Class 3, PG II in UNRTDG (UN2058).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 240 degC (NFPA (13th, 2006)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on LD50 values of >3200 mg/kg, >5000 mg/kg, 6200 mg/kg, 7660 mg/kg and 5600 mg/kg for rats (SIDS (2000)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on LD50 values of 2730 mg/kg and >5000 mg/kg for rabbits (SIDS (2000)), the substance was classified as "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on a LC50 value of 57 mg/L/4h (16186 ppmV/4h) for rats (SIDS (2000)), the substance was classified into Category 4. Since the LC50 value was lower than 90% of saturated vapour pressure concentration (65789.5 ppmV), the classification criteria for gas was adopted.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on results of skin primary irritation index (PII: 2.83) after application for 4-hour in a rabbit test (OECD TG404) (SIDS (2000)) and "strong irritating "after application for 24-hour in another rabbit test (SIDS (2000)), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on results of "irritating" in 4/10 rabbits in a Draize test (SIDS (2000)) and "marked irritation "in another rabbit test (SIDS (2000)), the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - There is a result of not skin sensitizing in 29 volunteers in a maximization test with a 1% solution in petrolatum (SIDS (2000)). It is reported that this result may not totally preclude a hazard of sensitization of the concentrated material after repeated exposure, but the material is not regarded as a potent sensitizer (SIDS (2000)). Since this report does not provide a clear no skin sensitization conclusion, classification as "Not classified" is questionable, therefore, the substance was classified as "Classification not possible".
5 Germ cell mutagenicity Not classified - - - - Based on negative result in a intraperitoneal injection mouse bone marrow micronucleus test (OECD TG474) (in vivo somatic cell mutagenicity tests) (SIDS (2000)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there is a report of a negative Ames test (SIDS (2000)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - No data available. As relevant information, according to assessment in SIDS (SIDS (2000)), it is concluded that the substance is highly unlikely to cause selective fetal toxicity and also not expected to exert prenatal toxicity from the reproductive and developmental toxicity data of the structurally related propionaldehyde, isobutyraldehyde and 3-methylbutanol-1.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a report that seven chemists, who were accidentally exposed to the substance leaking from a laboratory apparatus for several days, showed toxic effects such as tightness in the chest, irritation of the upper respiratory tract, cough, dyspnea. All individuals recovered rapidly following removal of the source of the leak (SIDS (2000)). Additionally there is a report that the mucus membranes of the nasal and the upper respiratory tract are affected upon exposure, producing a burning sensation, bronchial constriction, choking, and coughing (HSDB (2003)). The compound was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available. As relevant information, there is a report that "The relatively uniform toxicity profiles of aldehydes allow an estimation of toxicity of this product on the basis of data of aldehydes. For systemic effects in the tested aldehydes the NOAEL for oral uptake is 300 mg/kg, the NOAELs for inhalation are >150 ppm" (SIDS (2000)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 2 from its 96h-LC50 = 3.25 mg/L for fish (Fathead minnow) (SIDS, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since it is rapidly degradable (decomposition after 10 days by OECD TG302B: 99% (SIDS, 2004)) and its bioaccumulative potential is estimated to be low (log Kow = 1.23 (PHYSPROP Database, 2009)) though its acute toxicity is Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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