GHS Classification Result

Chemical Name：5-Ethyl-2-methylpyridine
CAS：104-90-5

Result：
ID: 21A3521
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Classified into Category 4 since flash point 70 degC (closed-cup) (SIDS (access on Jul. 2009)) is >60 degC and <=93 degC.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Auto-ignition point is 503.9 degC (HSDB (2003)) exceeding 70 degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		LD50 values of 1737 mg/kg bw (OECD TG401), 710 mg/kg (SIDS (1995)) and 800 - 1600 mg/kg (PATTY (5th, 2001)) for rats correspond to Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 1000 mg/kg bw for rabbits (SIDS (1995)), the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data. As relevant information, there is information of an LC50 value for rats of 540 ppm/4h (RTECS (2006)). Since the LC50 value was lower than 90% of saturated vapour pressure concentration (1881 ppm), the test was considered to be conducted for vapour with almost no included mists.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available. As relevant information, mortality occur in animals after inhalation to 12,000 ppm for 1-hour or 40-min, and 4000 ppm for 4-hour or 20-min (PATTY (5th, 2001)).
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a rabbit test (OECD TG404), 1-hour after removal of the wrapping a black discolouration was noted at all test sites, and on day 1, the test sites were covered by hard indented skin. The skin surrounding the test sites reacted with slight to moderate edema and moderate to severe erythema, but this irritation completely regressed and was not noted on 14 day observation (SIDS (1995)). Based on these results, the substance was determined to be "corrosive" (SIDS (1995)). In addition, since there are reports "it is a severe skin irritant" or "skin contact corrosive" (PATTY (5th, 2001)), the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on a report that degree of injury was 9 of 10 by application to eye in rabbit test (HSDB (2003)), a report of severe eye irritant (PATTY (5th, 2001)) and classification as a skin corrosive substance (SIDS (1995)), the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Although there is a report that the substance did not cause skin sensitization in a guinea pig test (PATTY (5th, 2001)), classification was not possible since the detailed data such as test method and positive animal ratio, are not clear.
5 Germ cell mutagenicity Not classified - - - - Based on negative result in a oral mouse erythrocyte micronucleus test (OECD TG474 (GLP)) (in vivo somatic cell mutagenicity tests) (SIDS (1995)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (SIDS (1995)), and generally negative but some positive results in human lymphocytes chromosome aberration tests (SIDS (1995)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on results in a one-generation test with rat by oral administration (OECD TG421 (draft)) in which 3 females showed total litter loss at a dose in which general toxicity such as poor bodyweight gains and salivation in parental animals was manifested (SIDS (1995)), the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based in a report that the LD50 value was 1737 mg/kg (within the guidance value range for Category 2) and symptoms such as lethargy, lacrimation, ataxia, tachypnea were observed in a rat acute oral toxicity test (OECD TG401) (SIDS (1995)) and a report of nervous system depression as one of major actions of pyridine and alkyl derivatives (HSDB (2003)), the substance was classified into Category 2 (nervous system). As relevant information, there is a report that emphysema of the lungs, congestion and edema are caused by inhalation exposure to rat (PATTY (5th, 2001)), but these findings were observed at high concentration exceeding the guidance value range.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 28-day repeated oral dose toxicity test with rats (OECD TG407), elevated BUN, creatinine, AST, and increased relative liver and kidney weights were observed at 300 mg/kg/day (90-day equivalent: 93.3 mg/kg/day). Hyaline droplets nephropathy was noted in males at 95 mg/kg/day (90-day equivalent: 29.5 mg/kg/day) and higher dose levels (SIDS (1995)). These level observed effects are within the guidance value range for Category 2 and the liver and kidney are regarded as target organs. However, the effects in the liver and kidney are not used as the basis of classification, since only blood biochemical and organ weight changes, but no histopathological changes were observed in the liver. Hyaline droplets nephropathy is a male rat specific lesion and is not applicable to human. Additionally, there is a report that ten daily oral administration of 300 mg/kg (90-day equivalent: 33.3 mg/kg, within the guidance value range for Category 2) to rats caused karyocytolysis of neurosecretory cells of the hypothalamic-hypophyseal system, leading to the appearance of cell ghosts (HSDB (2003)). However, this information is not reported in other assessment documents other than this document in List 2 and the relationship with specific adverse effects is not clear. Since there are no evidence of adverse effects at dosing levels within the guidance value range and no data at dose levels exceeding the upper limit of the guidance value range, classification was not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3 from its 48h-EC50 = 39.6 mg/L for Crustacea (Daphnia magna) (SIDS, 2005).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Classified into Not classified since it is rapidly degradable (degradation by OECD TG301E: 77% (SIDS, 2005)) and its bioaccumulative potential is estimated to be low (log Kow = 2.27 - 2.52 (SIDS, 2005)) though its acute toxicity is Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information