GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Pentafluoroethane
CAS：354-33-6
Result：
| ID: | 21A3522 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2009 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （March, 2009） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Not classified | - | - | - | - | Not combustible (SIDS (2005)) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Not oxidizing (SIDS (2005)) |
| 5 | Gases under pressure | Low pressure liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Critical temperature is 66.3 degC (Ullmanns (E) (6th, 2003)) exceeding 65 degC. |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to gaseous substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | - | Based on a LDLo of >800,000 ppm/4h (SIDS (2005)) in a rat test (OECD TG403 (GLP)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on a negative result in an inhalation mouse bone marrow micronucleus test (OECD TG474) (in vivo somatic cell mutagenicity tests) (SIDS (2005)), the substance was classified as "Not classified". As relevant information, from in vitro tests, there are reports of a negative Ames test (SIDS (2005), PATTY (5th, 2001)), and negative chromosomal aberration tests using Chinese hamster ovary cells and lung cells, and human lymphocytes (SIDS (2005), PATTY (5th, 2001)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In rat and rabbit developmental tests by inhalation exposure during organogenesis period (OECD TG414), no adverse effects on fetal development were reported under condition where general toxicity in maternal animals (unsteady gait for rats, decreased food consumption for rabbits) were manifested (SIDS (2005)). However, classification was not possible due to lack of data for sexual function and fertility. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No mortality or significant clinical signs other than transient body weight loss were observed after inhalation exposure to rats at approximately 500,000 to 700,000 ppm (ECETOC JACC (1994)). At 800,000 ppm, clinical signs such as ataxic gait and abnormal respiration were observed in all exposed rats but disappeared one hour after the exposure and no remarkable findings were observed during pathology examinations (SIDS (2005)). Although the substance corresponds to "Not classified" with inhalation exposure since these test concentrations exceed the upper limit of the guidance value range, classification was not possible due to lack of data with other exposure routes (oral and dermal). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In 4-week (OECD TG412) and 13-week (OECD TG413) inhalation tests with rats, no significantly toxic effects were observed. NOAECs were reported to be 50,000 ppm (90-day equivalent: 15386 ppm) and 50,000 ppm, respectively (SIDS (2005)). Although the substance corresponds to "Not classified" with inhalation exposure since NOAECs exceeded the upper limit of the guidance value range, classification was not possible due to lack of data with other exposure routes (oral and dermal). |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | Classified into Not classified since values estimated by QSAR are 96h-LC50 = 274 mg/L for fish, 48h-EC50 = 283 mg/L for Crustacea, 96h-EC50 = 172 mg/L for algae (SIDS, 2006 for any) and these estimated values are cited by SIDS and therefore reliable under the circumstances where it is difficult to obtain measured value. |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Classified into Not classified since it is not non-water soluble (water solubility: 923 mg/L (PHYSPROP Database, 2009)) and its acute toxicity is Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |