GHS Classification Result

Chemical Name:p-Methoxynitrobenzene
CAS:100-17-4

Result:
ID: 21A3524
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Classified into Not classified since the substance is classified into Division 6.1, PG III in UNRTDG (UN3458) though it contains chemical groups (N-O) associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Type G - - - - Classified into Type G since the substance is classified into Division 6.1, PG III in UNRTDG (UN3458) though there are chemical groups present in the molecule associated with explosive properties (but not self-reactive properties).
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Auto-ignition point is 458 degC (Chemical Risk Information Platform (CHRIP) (2009)) exceeding 70 degC.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Classified into Not classified since the substance is combustible and classified into Division 6.1, PG III in UNRTDG (UN3458).
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on LD50 values of 2600 mg/kg and 4700 mg/kg for rats (BUA 10 (1987)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on a LD50 value of >16000 mg/kg for rats (BUA 10 (1987)), the substance was classified as "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Based on a result of "no irritant" in a 24-hour exposure test with rabbits (BUA 10 (1987)), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Based on results in rabbit test that the irritant effect was greatest one hour after treatment, reaching a value of 7 on Draize score (max. 110), there was no observable damage to the epithelium of the cornea, and after 96-hour the irritant effect was no longer observable (BUA 10 (1987)), the substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a positive Ames test (BUA 10 (1987)), a negative Chinese hamster V79 cell gene mutation test (HGPRT test) (BUA 114 (1993)), and a negative Chinese hamster V79 cell chromosomal aberration test (BUA 114 (1993)). In addition, the substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There are reports for 104-week feeding carcinogenicity tests with rats and mice. In the rat test (dose level: 2000 - 8000 ppm in diet), increased incidences of hepatocellular adenoma in males, adenocarcinoma of the uterus and hepatocellular adenoma in females were observed (Japan Industrial Safety and Health Association: Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare (2003)). In the mouse test (dose level: 5000 - 2000 ppm in diet), increased incidences of hepatoblastoma and hepatocellular carcinoma in males and hepatocellular adenoma in females were observed (Japan Industrial Safety and Health Association: Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare (2003)). Based on these tests, since there is sufficient evidence to demonstrate carcinogenicity for rats and mice at high dose level, therefore, the substance was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there is a report that necropsy findings such as fatty degradation of the liver with large and fine fat droplets and parenchymatous degradation of the kidneys with fine fat droplets were noted in an oral acute toxicity test with rats (LD50: 4700 mg/kg) (BUA 10 (1987)), the dose level exceeded the guidance value range. Effects at dose level near the cut-off value are not clear. Therefore, classification was not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a 28-day repeated oral dose toxicity test with rats, unspecific symptoms coupled with slightly increased liver weights occurred at the highest dose level of 200 mg/kg (90-day equivalent: 62.2 mg/kg/day) (BUA 114 (1993)). The dose level is within the guidance value range. However, classification was not possible due to lack of other data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Classified into Category 3 from its 24h-EC50 = 13.5 mg/L for Crustacea (Daphnia magna) (BUA 114, 1996).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Classified into Not classified since its 21d-NOEC = 3.2 mg/L for Crustacea (Daphnia magna) (ECETOC TR91, 2003), 72h-EC10 = 3.9 mg/L for algae (green algae) (BUA 114, 1996), chronic aquatic toxicity NOEC >1 mg/L though its acute toxicity is Category 3 and it is not rapidly degradable (Non-biodegradable, decomposition by BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1977).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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