GHS Classification Result

Chemical Name:N,N'-Dinitrosopentamethylenetetramine
CAS:101-25-7

Result:
ID: 21A3530
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Classified into Not classified since the substance is classified into Division 4.1 (Flammable solids, self-reactive substances and solid desensitised explosives) in UNRTDG (UN3224: SELF-REACTIVE SOLID) though it contains chemical groups (nitroso group) associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Type C Danger H242: Heating may cause a fire P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P411: Store at temperatures not exceeding ... degC/... degF.
P420: Store away from other materials.
P501: Dispose of contents/container to ...
Classified into Division 4.1 in UNRTDG (UN3224 (Self-reactive substances C, solid) (containing the concentration of 82 mass%) since the substance contains chemical groups (nitroso group) associated with explosive properties present in the molecules. In related to this, the regulation is available that is "Limit to only substances having a boiling point of below 150 degC which contain diluent nonreactive with this substance". The substance is classified into Type C since it is judged that the substance with this concentration is being distributed.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance contains oxygen which is chemically bonded to atoms except carbon and hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on a LD50 value of 940 mg/kg bw for rats (IARC 11 (1976)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data from in vivo mutagenicity tests. In vitro test information from List 3, there are reports of a positive Ames test, a positive rat hepatocyte chromosome aberration test and a positive gene mutation test with mouse lymphocytes (RTECS (2006)). In addition, the substance is an existing chemical substance for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Not classified - - - - Based on the classification of Group 3 by IARC, the substance was classified as "Not classified". In addition, there is a report that no tumors were induced in rats given 9 mg/animal by oral gavage for 1-year and observed for 6-month (IARC 11 (1976)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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