GHS Classification Result

Chemical Name:8-Quinolinol
CAS:148-24-3

Result:
ID: 21A3531
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government (March, 2009)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on a LD50 value of 1200 mg/kg for rats (NTP TR276 (1985)), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
A LD50 value of 6 mg/animal (200 - 300 mg/kg; converted using body weight of 20 - 30 g) for mice (IARC 13 (1977)) corresponds to Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data. As relevant information, a LC50 value was >1210 mg/m3/6h (>1800 mg/m3/4h) (RTECS (2008), the original literature: Journal of the American College of Toxicology.), classification was not possible since the value was in multiple categories.
2 Skin corrosion/irritation Not classified - - - - Based on a result of "mild" in the Draize test where 500 mg was applied to the skin of rabbits for 24-hour (RTECS (2008); Journal of the American College of Toxicology), the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on results that injection into rabbit cornea caused very slight reaction (HSDB (2002)) and "mild irritating" in a rabbit Draize test (RTECS (2008); Journal of the American College of Toxicology), the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on negative results in an intraperitoneal injection mouse bone marrow micronucleus test and a chromosome aberration test (in vivo somatic cell mutagenicity tests) (NTP DB (access on Aug. 2009)), the substance was classified as "Not classified". As relevant information, a negative result is reported in intraperitoneal injection mouse bone marrow sister chromatid exchange (SCE) analysis (in vivo genotoxicity tests in somatic cells) (NTP DB (access on Aug. 2009). From in vitro tests, there are reports of a positive Ames test, a positive mouse lymphoma test and a positive CHO cell chromosomal aberration test (NTP DB (access on Aug. 2009)). The substance is an existing chemical substance for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Not classified - - - - Based on the classification of "Group 3" in IARC (IARC suppl.7 (1987)), the substance was classified as "Not classified". As relevant information, in 2-year feeding tests with rats and mice, there was no evidence of carcinogenicity (NTP TR276 (1985)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In a report of 13-week feeding tests with rats and mice (NTP TR276 (1985)), no exposure related effects were observed in all examinations including histopathological examination except for decreases in body weight gain and food consumption at the highest dose level of 12,000 ppm (660 mg/kg/day) in rats or 6,000 ppm (774 - 888 mg/kg/day) in mice. Although the substance corresponds to "Not classified" with oral exposure since these levels exceed the guidance value range, classification was not possible due to lack of data with other exposure routes.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 from its 72h-EC50 = 0.52 mg/L for algae (Pseudokirchneriella subcapitata) ((Ministry of the Environment), 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (Non-biodegradable, decomposition by BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1994)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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