GHS Classification Result

Chemical Name：alpha,4-Dichlorotoluene
CAS：104-83-6

Result：
ID: 21A3532
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2009
Reference Manual: GHS Classification Guidance by the Japanese Government （March, 2009）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Auto-ignition point is >650 degC (Hommel (1996)) exceeding 70 degC.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance contains chlorine which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 500 mg/kg bw for rats ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (Access in August 2009), OECD TG423), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a LD50 value of 1287 mg/kg bw for rats (BUA 236 (2002)), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In a rabbit skin irritation test (OECD TG404), mean redness scores were 0.7, 0.7, and 0.3 at 24, 48 and 72-hour, respectively, after patch removal. The effect was relieved on day 3, edema was recovered within 24-hour. The test result was determined as "not irritating" (BUA Report 236 (2002)). Based on these data, the substance was classified as "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - In a rabbit eye irritation test (OECD TG405), mean scores at 24, 48 and 72-hour after application were 0.3, 0, and 0.3 for corneal opacity (recovered on day 2); 0.7, 0.7, and 0.7 for conjunctivitis (recovered on day 3); and 0, 0.7, and 0.7 for conjunctival swelling (recovered on day 3). There was no damage on the iris. The substance was classified as "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on a result of positive ratio 100% (10/10), a conclusion of sensitizing was made in a guinea pig maximization test (OECD TG406 (GLP)) (BUA Report 236 (2002)). The substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a result of positive in oral rat dominant lethal test (in vivo heritable germ cell mutagenicity tests), this test is invalid since the detailed data are not clear (BUA Report 236 (2002)). Therefore, classification was not possible due to lack of appropriate data from in vivo mutagenicity tests. Additionally, in this report, effect on chromosome is negative (BUA Report 236 (2002)). As relevant information, from in vitro mutagenicity tests, there are reports of negative in 3/4 Ames tests ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Aug. 2009), BUA Report 236 (2002)), and a positive chromosomal aberration test ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Aug. 2009)). The substance is an existing chemical substance for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data. In a rat test, there was no report for parental general toxicity but there was information that preimplantation and postimplantation embryo deaths were observed. (BUA Report 236 (2002)). Additionally, toxic effects on parental sexual function and fertility, and embryo fetal toxicity appeared. Due to the defect of the data, the information is not used as the basis for the determination of classification.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on a report that narcosis was a symptom of intoxication observed in a rat oral test (BUA 236 (2002)), the substance was classified into Category 3 (narcotic effects). Additionally, stomach perforation and stomach with fused spleen were also observed at a level of LD50 value (1090 mg/kg bw) in this test (BUA 236 (2002)). The relationship with guidance value range is unclear.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into category 2 from its 96h-LC50 = 2.24 - 2.5 mg/L for fish (Golden orfe) (BUA 236, 2004)
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (Non-biodegradable, decomposition by BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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